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Vor die Therapie setzten die Gotter die Diagnose. Otto NiigeJi Renal biopsy has decisively enriched renal diagnostics. Kidney diseases may be monitored during their entire course, and new techniques - such as immunofluorescence and electron microscopy - may be systematically applied, resulting in novel insights into the morphogenesis, pathogenesis, and etiology of kidney lesions. These insights, in turn, have served as new starting points, in the spirit of the quotation above, for the institution of causal therapy by the clinician. This work presents our findings based on 20 years of experience in evaluating renal biopsies. As of the end of 1974, our computer-supported, systematic clinical, morphologic, and follow-up evaluation of case material consisted of over 2000 biopsies, including 679 examined by electron microscopy and 400 by immunofluorescence microscopy. The subsequent 500 biopsies (400 studied by electron microscopy and 300 by immunofluorescence) were con sidered qualitatively only. In order to enhance qualitative findings with quantitative data, it was necessary to devise new methods for quantifying electron-microscopic findings. Additionally, we attempted to correlate cyto logic and immunofluorescent observations to integrate the isolated findings of electron microscopy into a vital cytologic pattern of reactions. We also attempted to evaluate the almost overwhelming flood of publications, especially those appearing within the last 10 years. The idea for this book was conceived a decade ago. At that time, however, our own experience in renal biopsy diagnostics seemed insufficient to sup port such a major undertaking.
List of contents
I. Technique and General Pathology.- 1. Clinical and Procedural Aspects.- 2. Clinician's Role in Renal Biopsy Management and Processing.- 3. Renal Biopsy Management and Processing by the Pathologist.- 4. Histology of Normal Kidney Tissue.- 5. Introduction to Renal Histopathology.- 6. Histopathology of the Glomerulus Under High Power Magnification.- 7. Histopathology of the Juxtaglomerular Apparatus (JGA).- 8. Histopathology of the Renal Tubules.- 9. Histopathology of the Renal Interstitium.- 10. Histopathology of the Renal Vessels.- 11. Immunohistopathologic Parameters.- 12. General Differential Diagnosis Between Non-Glomerulonephritic Nephropathies and Glomerulonephritis.- II. Histopathology of Specific Renal Disease States.- 13. General Aspects of Glomerulonephritis.- 14. The Diffuse Forms of Glomerulonephritis.- 15. Focally Accentuated Glomerulonephritis.- 16. Glomerulonephritic Contracted Kidney (Nonclassifiable Glomerulonephritis, End-Stage Kidney).- 17. Special Forms of Glomerulonephritis.- 18. Glomerular Minimal Change.- 19. Glomerulonephrosis and Glomerulosclerosis.- 20. Inflammatory Interstitial Renal Lesions.- 21. Kidney Tuberculosis and Rare Kidney Infections.- 22. Hydronephrosis and Nephrohydrosis.- 23. Enzymopathic, Metabolic Renal Diseases.- 24. Renal Changes Caused by Impairment of the Circulatory System.- 25. Renal Changes Caused by Vascular Disease.- 26. Unilateral Contracted Kidney and Renal Hypertension.- 27. The Kidney in Radiation Injury.- 28. Malformations of the Kidney.- 29. Kidney Tumors.- 30. Kidney Transplantation.- References.
Summary
Vor die Therapie setzten die Gotter die Diagnose. Otto NiigeJi Renal biopsy has decisively enriched renal diagnostics. Kidney diseases may be monitored during their entire course, and new techniques - such as immunofluorescence and electron microscopy - may be systematically applied, resulting in novel insights into the morphogenesis, pathogenesis, and etiology of kidney lesions. These insights, in turn, have served as new starting points, in the spirit of the quotation above, for the institution of causal therapy by the clinician. This work presents our findings based on 20 years of experience in evaluating renal biopsies. As of the end of 1974, our computer-supported, systematic clinical, morphologic, and follow-up evaluation of case material consisted of over 2000 biopsies, including 679 examined by electron microscopy and 400 by immunofluorescence microscopy. The subsequent 500 biopsies (400 studied by electron microscopy and 300 by immunofluorescence) were con sidered qualitatively only. In order to enhance qualitative findings with quantitative data, it was necessary to devise new methods for quantifying electron-microscopic findings. Additionally, we attempted to correlate cyto logic and immunofluorescent observations to integrate the isolated findings of electron microscopy into a vital cytologic pattern of reactions. We also attempted to evaluate the almost overwhelming flood of publications, especially those appearing within the last 10 years. The idea for this book was conceived a decade ago. At that time, however, our own experience in renal biopsy diagnostics seemed insufficient to sup port such a major undertaking.
