Glucagon III

Glucagon III complements Glucagon I and II published in 1983 in this series as Vols. 66/I and II. These three volumes truly represent a "glucagon encyclopedia" and as such have no competitors in the scientific literature worldwide. In this volume, the most recent data on glucagon molecular biology are reviewed together with clinically relevant information on the role of glucagon in the pathophysiology of diabetes, the place of glucagon in medical imaging or in emergency medicine. Chapters are devoted to newly identified members of the glucagon family such as glucagon-like peptide-1 (GLP-1) and oxyntomodulin. Glucagon III is a comprehensive review of all information published on this important hormone since 1983 and is the reference book on the subject.

List of contents

1 The Industrial Production of Glucagon.- A. Introduction.- B. Production.- C. Analysis of Recombinant Human Glucagon.- D. Stability.- References.- 2 The Glucagon Gene and Its Expression.- A. Introduction.- B. Structure.- C. Expression.- D. Conclusions.- References.- 3 Preproglucagon and Its Processing.- A. Introduction.- B. Tissue-Specific Post-translational Processing of Proglucagon.- C. Role of Prohormone Convertases in Proglucagon Processing.- D. Secondary, Postsecretory Processing of Proglucagon-Derived Peptides.- E. Conclusions.- References.- 4 The Glucagon Receptor Gene: Organization and Tissue Distribution.- A. Introduction.- B. Cloning of the Glucagon Receptor.- C. Organization of the Glucagon Receptor Gene.- D. Tissue Distribution of the Glucagon Receptors.- E. Tissue Distribution of Glucagon Receptor Transcripts.- F. Regulation of Glucagon Receptor Gene Expression.- G. Structure/Function Analysis of the Glucagon Receptor.- H. Human Glucagon Receptor.- I. Conclusions.- References.- 5 Mode of Action of Glucagon Revisited.- A. Introduction.- B. Glucagon Actions Mediated Through Glucagon Receptors.- C. Glucagon is Processed by Its Target Cells.- D. Action of Mini-glucagon [Glucagon (19-29)] in Liver.- E. Mini-glucagon Action in Heart.- F. Glucagon and Mini-glucagon Act in Concert.- G. Conclusion and Perspectives.- References.- 6 Pulsatility of Glucagon.- A. Introduction.- B. Oscillations in Glucagon Plasma Levels.- C. Pulsatile Glucagon Secretion In Vitro.- D. Pulsatile Glucagon Delivery In Vitro.- E. Pulsatile Glucagon Delivery In Vivo.- F. Conclusions.- References.- 7 Glucagon and Diabetes.- A. Introduction.- B. Diabetogenic Effects of Glucagon.- C. The A Cell in Diabetes.- D. Circulating Glucagon Levels in Diabetes.- E. Glucagon Dysfunction in Diabetes.- F.Role of Glucagon Excess in the Metabolic Abnormalities of Diabetes.- G. Therapeutic Implications.- H. Conclusions.- References.- 8 The Search for Glucagon Antagonists.- A. Glucagon as a Drug Target.- B. Search for a Glucagon Antagonist.- References.- 9 Glucagon and Glucose Counterregulation.- A. Introduction.- B. Glycemic Action of Glucagon.- C. Glucagon Secretion.- D. Role of Glucagon in Glucose Counterregulation.- E. Conclusions.- References.- 10 Modes of Glucagon Administration.- A. Introduction.- B. Classic Routes of Administration.- C. New Routes of Glucagon Administration.- D. Conclusions.- References.- 11 The Place of Glucagon in Emergency Medicine.- A. Hypoglycemia.- B. Cardiovascular Insufficiency.- C. Vascular Effects.- D. Renal/Urologic Effects.- E. Shock.- F. Respiratory Effects.- G. Gastrointestinal Effects.- H. Radiographic Studies.- I. Adverse Effects.- References.- 12 The Place of Glucagon in Medical Imaging.- A. Introduction.- B. Upper Gastrointestinal Tract.- C. Small Bowel.- D. Large Bowel.- E. Biliary Tract.- F. Other Applications.- G. Side Effects and Contraindications.- References.- 13 The Glucagon Test for Evaluation of Insulin Secretion.- A. Introduction.- B. Methodological Aspects.- C. Comparison with Other Stimuli.- D. Clinical Applications.- E. Conclusions.- References.- 14 Glucagon and the Control of Appetite.- A. Introduction.- B. Prandial Glucagon Secretion.- C. Glucagon Administration and Food Intake.- D. Glucagon Antagonism and Food Intake.- E. Mechanism of Glucagon Satiety.- F. Clinical Aspects.- G. Conclusions.- References.- 15 Glucagonoma and Its Management.- A. Introduction.- B. Diagnosis and Localization of the Tumor.- C. Management of the Glucagonoma Syndrome.- D. Prognosis.- E. Conclusions.- References.- 16 Structure and Functionof the Glucagon-Like Peptide-1 Receptor.- A. Introduction.- B. GLP-1 Receptor.- C. Conclusions.- References.- 17 Physiology and Pathophysiology of GLP-1.- A. The Incretin Concept.- B. Origin, Processing, Secretion and Fate of GLP-1.- C. Tissue Distribution of GLP-1 Receptors and Biological Actions.- D. Signal Transduction of the GLP-1 Receptor.- E. Pathophysiological Relevance?.- References.- 18 Potential of GLP-1 in Diabetes Management.- A. Introduction.- B. Actions of GLP-1 on Blood Glucose in Humans.- C. Gastrointestinal Effects of GLP-1 in Humans.- D. GLP-1 and Diabetes.- E. GLP-1 Metabolism in Normal and Diabetic Subjects.- F. Conclusion and Outlook.- References.- 19 Oxyntomodulin and Its Related Peptides.- A. Introduction.- B. Biological Characteristics of Oxyntomodulin.- C. Conclusions.- References.

Product details

• Assisted by: Pierr J Lefebvre (Editor), Pierre J Lefebvre (Editor), Pierre J. Lefebvre (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 04.12.2012
• EAN: 9783642647185
• ISBN: 978-3-642-64718-5
• No. of pages: 349
• Illustrations: XX, 349 p. 1 illus. in color.
• Series: Handbook of Experimental Pharmacology; Handbook of Experimental Pharmacology
• Subject: Natural sciences, medicine, IT, technology > Medicine > Pharmacy