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To give an update in the field of haemostasis scientists andclinicians fromoverseas and European countries met to dis-cuss the new trends in pathophysiology and clinical impli-cations. This book is devoted to the interactions of endo-thelial functions, tissue factors, coagulation inhibitorsand haemostasis as well as detection and prophylaxis ofthromboembolism. Data are presented of significant new re-search work on molecular and clinical approaches to diseasesin haemostasis.
List of contents
Endothelial Functions and Haemostasis.- Structure, Shape and Function of Glycosaminoglycans.- Structure and Metabolism of Glycosaminoglycans.- Fibrin Polymerization and Its Role in Regulating Haemostasis.- Function of von Willebrand Factor in Plasma.- Biosynthesis and Assembly of the Factor VIII - von Willebrand Factor Complex.- Modulation of Endothelial Cell Function by Hypoxia: Perturbation of Barrier and Anticoagulant Function and Induction of a Novel Procoagulant Activity.- Tissue Factors and Endothelium.- Platelet Adhesion; A Concerted Action of Hemodynamic and Biochemical Processes.- Modulation of Endothelial Functions by Advanced Glycosylation End Products.- Procogulant Activities of Leukocytes.- Cytokine Induced Stimulation of Endothelial Cells in Vitro.- Anti-Platelet Treatment of Metastasis.- The Molecular Anatomy of Vitronectin as Extracellular Regulator Protein: Multifunctional Properties of the Heparin-Binding Domain.- Mode of Action of Annexin V (Vascular Anticoagulant Alpha), A Protein Synthesized by the Vessel Wall.- Coagulation Inhibitors and Haemostasis.- Clinical Pharmacologal Profile of Low Molecular Weight Heparins.- Anticoagulant Actions of Sulphated Polysaccharides.- Development of Synthetic Proteinase Inhibitors as Anticoagulant Agents.- Antithrombin and Its Deficiency States.- "New" Coagulation Inhibitors.- Biological Function of Vitamin K Antagonists.- Plasminogen Activator Inhibitors: Biological Effects.- Fibrin-Specific Clot Lysis with Single Chain Urokinase-Type Plasminogen Activator (scu-PA).- Antibody - Mediated Thrombolysis: Promise and Problems.- Thromboembolism: Detection and Prophylaxis.- Causation and Prevention of Coronary Thrombosis: Present Situation.- Non-Invasiva Diagnostic Techniques in Deep Vein Thrombosis.- Evaluationof the Bleeding Effects of Antithrombotic Drugs.- List of Participants.- List of Sponsors.
Summary
To give an update in the field of haemostasis scientists and
clinicians fromoverseas and European countries met to dis-
cuss the new trends in pathophysiology and clinical impli-
cations. This book is devoted to the interactions of endo-
thelial functions, tissue factors, coagulation inhibitors
and haemostasis as well as detection and prophylaxis of
thromboembolism. Data are presented of significant new re-
search work on molecular and clinical approaches to diseases
in haemostasis.
