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Even if in the last years more information on sepsis and new treatments has become available, mortality rate is however high. In fact, the complexity of the several biohumoral factors involved in this process is difficult to understand. Another major problem is the consequent organ failure, which grows in a sequential way and in relation with the lesion gravity and the functional reserves of the patient. The volume presents the most recent results of research in this field.
List of contents
Introductory Remarks.- Sepsis and Organ Dysfunction - Basics, Controversies, Rationale.- Sepsis and Organ Dysfunction: From Chaos to Rationale.- Alveolar Epithelium in Host Defence: Cytokine Production.- Phagocytosis and Lung Injury.- Dual Role of Neutrophil ?-Defensins in Lung Inflammation.- Epithelial Injury in Sepsis and ARDS: Role of Leukocyte-Derived Proteases.- Pro-and Anti-Inflammatory Cytokines and Apoptosis in Acute Lung Injury.- The Role of Interleukin-10 During Systemic Inflammation and Bacterial Infection.- Cardiovascular Surgery: Modulation of the Inflammatory Reaction.- Microcirculation in Critical Illness.- Microbial Translocation: From Myth to Mechanism.- Empirical Antibiotic Treatment in ICU Patients.- Rotation of Antibiotics - A New Strategy for Prescription in the Intensive Care Unit.- Diagnostic Approach to Sepsis - State of the Art.- Septic Shock Therapy.- Sepsis Trials in Children.- Sepsis and Clinical Trials: A New Era in Anti-Sepsis Therapies.- Evolving Concept and Challenges in Sepsis and MODS.
Summary
Even if in the last years more information on sepsis and new treatments has become available, mortality rate is however high. In fact, the complexity of the several biohumoral factors involved in this process is difficult to understand. Another major problem is the consequent organ failure, which grows in a sequential way and in relation with the lesion gravity and the functional reserves of the patient. The volume presents the most recent results of research in this field.
