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During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical con stitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewil dering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath taking insights into the molecular mechanisms used by nature for replicating, dis tributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller molecules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field.
List of contents
1. The Protein Translocation Machinery of the Endoplasmic Reticulum: The Signal Hypothesis Ten Years Later.- 2. Mechanism and Structural Basis for Recognition of Signal Peptides.- 3. Proteolytic Processing of Signal Peptides.- 4. The Posttranslational Processing of the Precursors of Secreted Peptides.- 5. Assembly of Multisubunit Membrane Proteins.- 6. Structure, Function, and Biosynthesis of Fatty Acid-Acylated Proteins.- 7. Biosynthesis of Endoplasmic Reticulum Membrane Proteins.- 8. Import of Proteins into Mitochondria.
Summary
With contributions by numerous experts
