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Soft tissue tumors are a very heterogeneous group of tumors in terms of histogenesis, morphology, cytogenetics, molecular biology, clinical manifestation, and prognosis. Their spectrum is fascinating for morphologists and basic scientists alike. Yet precisely this variability in the morphologic manifestation of soft tissue tumors, specifically their histologic and cytologic patterns, presents great difficulties to any effort to categorize them. Although many soft tissue tumors are today defined not only by histology but also by immunohistochemical, cytogenetic, and molecular biological findings, the histogenesis of many soft tissue tumors, in particular malignant ones, continues to be unknown. This is associated with the fact that the actual precursor cells that lead to these tumors have frequently not yet been identified. For this reason, the customary classification of malignant soft tissue tumors is primarily not histogenetic, but actually according to the dominant phenotype, however characteristic it is. Of course, an exact morphologic examination of soft tissue tumors con tinues to be an essential prerequisite for making a diagnosis and determining a therapy. The use of a wide range of additional modern examination techniques, however, can make a substantial contribution toward more precisely defining the biological behavior of a tumor, which without doubt can have therapeutic implications.
List of contents
Incidence of Soft Tissue Sarcomas in Adults.- Clinical Management of Soft Tissue Sarcomas.- Soft Tissue Sarcomas in the Kiel Pediatric Tumor Registry.- Molecular Biological Aspects of Soft Tissue Tumors.- Characteristic Chromosome Abnormalities and Karyotype Profiles in Soft Tissue Tumors.- DNA Ploidy in Soft Tissue Tumors: An Evaluation of the Prognostic Implications in the Different Tumor Types.- Heterogeneity in Malignant Soft Tissue Tumors.- Grading of Soft Tissue Sarcomas: Proposal for a Reproducible, Albeit Limited Scheme.- Fibrous Tumors and Tumor-like Lesions of Childhood: Diagnosis, Differential Diagnosis, and Prognosis.- Malignant Fibrous Histiocytoma: "A Fibrohistiocytic" or Primitive, Fibroblastic Sarcoma.- Recent Advances in Tumors of Adipose Tissue.- Classification of Rhabdomyosarcoma.- Spindle Cell Rhabdomyosarcoma: Histologic Variant of Embryonal Rhabdomyosarcoma with Association to Favorable Prognosis.- Alveolar Rhabdomyosarcoma: A Prognostically Unfavorable Rhabdomyosarcoma Type and Its Necessary Distinction from Embryonal Rhabdomyosarcoma.- Malignant Peripheral Neuroectodermal Tumor.- Leiomyosarcoma.- Malignant Peripheral Nerve Sheath Tumors.- Rare Soft Tissue Sarcomas.
