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The idea that the brain is an "immune-privileged site" has perhaps served to slow our realization that the intact brain can generate its own inflammatory reactions. These responses can be to peripheral infection, or they can arise from local, internal causes, for instance as a response to stress or to the se vere changes in neuronal activity in seizure or the loss of oxygen in stroke. We are also becoming increasingly aware of the contribution of local inflam matory reactions to certain neurodegenerative diseases such as Alzheimer's In fact, evidence is accumulating that inflammatory processes disease (AD). contribute to the progression of AD, suggesting the possibility of using cur rently available or novel anti-inflammatory agents to interfere with this terri ble disease. Correlations are also being made between inflammatory signs and mental illness, which is a new frontier of research. This book presents the current state of knowledge in a variety of areas relevant to neuro-immune interactions, with particular attention to AD.
List of contents
Organization of Inflammatory Processes in Alzheimer's Disease.- Glial Cytokines in Neurodegenerative Conditions.- Contributions of the Glial Injury Response to the Multifactorial Pathogenesis of Alzheimer's Disease.- Cytokine Communication Between Neurons and Glia and the Pathogenesis of Alzheimer's Disease.- Glial Hyperactivity During Aging as a Neuroinflammatory Process.- Mechanistic and Metaphorical Connections Between NF-KB and the Secreted Alzheimer's ?-Amyloid Precursor Protein.- Pathological and Biochemical Studies of Chronic Neuroinflammation May Lead to Therapies for Alzheimer's Disease.- Serotonine-Immune Interactions in Major Depression.- Responses in the Raphe-Hippocampal Serotonergic System During Peripheral Inflammation: Putative Role in Sickness Behaviour.- Neuronal Control of the Immune Response in the Central Nervous System: From Pathogenesis to Therapy.- Regulation of Cyclic AMP Synthesis in Microglial Cells and Possible Role of Cyclic AMP in Neuroprotection.- Cytokine and Anti-Inflammatory Drug Effects on Brain Trauma and Alzheimer's Disease Pathology in Transgenic Mice.- In vivo Involvement of the Cytokine LIF During Lesion-Induced Renewal of Olfactory Sensory Neurons in Adult Mouse.- Neuroglial Activation in the Nervous System Following Injury: Role of Cytokines.- Sickness Behavior: A Neuroimmune-Based Response to Infectious Disease.- Central Origin of IL-1? Produced During Peripheral Inflammation: Role of Meninges.- Vitamin D, a Hormone Involved in the Control of Neuro-immune Interactions in the Brain.
