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In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions. The development of this field over the past 2 decades reflects very much a modern trend of biological research. As more detailed knowledge accumulates, enigmatic phenomena turn into concepts which create their own enigmata. This process tends to favor the development of multiple, seemingly disconnected, research lines until simplicity emerges from chaos and unifying concepts substitute for controversy. It appears that the field of ADP-ribosylation reactions has not yet attained this latter stage. For example, with the identification of two different classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla tion and poly-ADP-ribosylation reactions, the field split very early into two separate branches of research. With the present volume, we have divided the task of reviewing these two classes of ADP ribosylation accordingly, although their coexistence in eukaryotes may involve a closer functional linkage than hitherto recognized.
List of contents
I Poly-ADP-Ribosylation Reactions (F. R. Althaus).- 1 Poly(ADP-Ribose): Structure, Properties, and Quantification.- 2 Poly(ADP-Ribose) Biosynthesis.- 3 Poly(ADP-Ribose) Catabolism.- 4 Nuclear Acceptor Proteins for Poly(ADP-Ribose) and the Functional Consequences of Poly-ADP-Ribosylation on the Acceptor Species.- 5 Poly-ADP-Ribosylation and Chromatin Organization.- 6 Poly-ADP-Ribosylation in the Recovery of Mammalian Cells from DNA Damage.- 7 Poly(ADP-Ribose), DNA Synthesis, and Cell Cycle Progression.- 8 Poly(ADP-Ribose), Cellular Differentiation, and Gene Expression.- 9 Poly(ADP-Ribose) in Inherited Human Diseases and Experimental Disease Models.- II Mono-ADP-Ribosylation Reactions (Ch. Richter).- 10 Signal Transduction.- 11 Cholera Toxin.- 12 Pertussis Toxin.- 13 Diphtheria Toxin.- 14 Cellular Transferases.- 15 Mitochondria.- 16 The Bond.
About the author
Dr. rer. silv. Christoph Richter, Jahrgang 1943, war bis 2007 als Wissenschaftlicher Mitarbeiter am Lehrstuhl Forstnutzung in Tharandt tätig. Er kann auf über 70 Veröffentlichungen und zehn Schutzrechte (u.a. Holzmerkmale, Rundholzsortierung, Holztechnologie, Werkstoffe aus nachwachsenden Rohstoffen und Recyclingprodukten, Forstliches Nebengewerbe) verweisen.
