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One person in four in the industrialized countries suffers
from hyperuricemia and is therefore at risk of developing
gouty arthritis, nephrolithiasis, or any of the other
consequences of urate deposition.
At present, far too little is known about urate deposition
and the mechanisms by which it occurs, as well as about its
clinical consequences, which include formation of toph; over
the helix of the ear or in bones close to joints that have
never exhibited an attack, development of bursitis, chronic
tendovaginitis leading to carpal tunnel syndrome, and gouty
paraplegia. Information on these matters is needed to
estimate the risks of hyperuricemia and to determine when
therapeutic intervention is indicated. The contributions and
discussions in this book, resulting from an international
symposium held in December 1990 in the Medizinische
Poliklinik in Munich, provide an up-to-date source of
current knowledge about hyperuricemia in man and its
clinical consequences.
List of contents
1 The Study of Inborn Errors of Metabolism - 40 Years of Experience at the Poliklinik of the University of Munich.- 2 The Enigma of Urate Deposition.- Precipitation and Deposition of Monosodium Urate Monohydrate Crystals in Tissues.- 3 Urate Depositions in Tissues.- 4 Renal Consequences of Hyperuricemia.- Urate and Uric Acid Crystal Reactions Within the Kidney - Clinical and Experimental Studies.- 5 Urate Deposition and Stone Formation in the Kidney in Renal Hypouricemia.- Acute Renal Insufficiency: Which Mechanisms Are Involved?.- 6 Epidemiology of Hyperuricaemia.- 7 Pathogenesis of Monosodium Urate Crystal-Induced Inflammation.- Crystal-Associated Inflammation: Some Mechanisms of Cellular Activation.- 8 The Course of Chronic Gout with Special Reference to Extra-articular Manifestations and Joints Not Affected by Acute Attacks.- 9 The Course of Chondrocalcinosis.- 10 Round Table Discussion.
About the author
Prof. Dr. med Nepomuk Zöllner, Facharzt für Innere Medizin, war von 1973 bis 1993 Vorstand der Medizinischen Poliklinik der Universität München. Das Hauptaugenmerk seiner klinischen und wissenschaftlichen Tätigkeit richtete er, auch als gelernter Biochemiker, auf ernährungsbedingte Krankheiten und auf Störungen des Stoffwechsels, speziell die Arteriosklerose, auf Verdauungsstörungen und Gelenkerkrankungen. Mit der Gicht hat er sich als Forscher wie als Arzt jahrelang - bis heute - intensiv beschäftigt. Professor Zöllner war Präsident der Deutschen Gesellschaften für Innere Medizin, für Verdauungs- und Stoffwechselkrankheiten und für Ernährung. Er ist Gründer und Ehrenpräsident der Europäischen Gesellschaft für die Erforschung des Purin(Harnsäure-)-Stoffwechsels.
Summary
At present the knowledge about the pathophysiological mechanisms of urate deposition and its clinical consequences is poor. The practitioner severely needs information for his every day work that enables him to estimate the risk of individual patients' susceptibility to diseases like gouty arthritis or nephrolithiasis.
