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Based on the results of the latest congress of the EuropeanAssociation for the Study of the Liver (EASL), this volumemakes excellent reading since it explores in detail therole of free radical reactions in liver diseases.Studies in recent years using various methods have shownthat free radicals play an important role in toxic liverdisorders. For this reason, the current scientific knowledgeis presented in this balanced, clinical portrayal. Theaccount refers to the many observations, experiencesandevaluations that have been made both clinically andexperimentally.Two major areas discussed concern the pathophysiologicalchanges by free radicals and the therapeutic possibilitiesthat have come to light.
List of contents
Role of Free Radical Reactions in Liver Diseases.- Oxidative Stress in Chemical Toxicity.- Relationships Between Free Radical Reactions and the Function of the Cytochrome P-450 System.- Regulation Mechanisms of Xenobiotics Metabolizing Liver Cytochrome P-450 and Toxicological Implications.- Lipid Peroxidation and Hepatocyte Damage in the Animal Model and in Human Patients.- Calcium, Phospholipase A2, and Eicosanoids in Toxigenic Liver Cell Injury.- Lipid Peroxidation and Associated Hepatic Organelle Dysfunction in Iron Overload.- Structural Principles of Flavonoid Antioxidants.- Role of Free Radical Reactions in Experimental Hyperlipidemia in the Pathomechanism of Fatty Liver.- Free Radical Reactions in the Pathomechanism of Amiodarone Liver Toxicity.
