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Informationen zum Autor John W. Stirling , The Centre for Ultrastructural Pathology, Adelaide, Australia Alan Curry , Manchester Royal Infirmary, Manchester, UK Brian P. Eyden , Christie NHS Foundation Trust, Manchester, UK Klappentext Diagnostic Electron Microscopy: A Practical Guide to Interpretation and Technique summarises the current interpretational applications of TEM in diagnostic pathology. This concise and accessible volume provides a working guide to the main, or most useful, applications of the technique including practical topics of concern to laboratory scientists, brief guides to traditional tissue and microbiological preparation techniques, microwave processing, digital imaging and measurement uncertainty.The text features both a screening and interpretational guide for TEM diagnostic applications and current TEM diagnostic tissue preparation methods pertinent to all clinical electron microscope units worldwide. Containing high-quality representative images, this up-to-date text includes detailed information on the most important diagnostic applications of transmission electron microscopy as well as instructions for specific tissues and current basic preparative techniques.The book is relevant to trainee pathologists and practising pathologists who are expected to understand and evaluate/screen tissues by TEM. In addition, technical and scientific staff involved in tissue preparation and diagnostic tissue evaluation/screening by TEM will find this text useful. Zusammenfassung Diagnostic Electron Microscopy: A Practical Guide to Interpretation and Technique summarises the current interpretational applications of TEM in diagnostic pathology. This concise and accessible volume provides a working guide to the main, or most useful, applications of the technique including practical topics of concern to laboratory scientists, brief guides to traditional tissue and microbiological preparation techniques, microwave processing, digital imaging and measurement uncertainty.The text features both a screening and interpretational guide for TEM diagnostic applications and current TEM diagnostic tissue preparation methods pertinent to all clinical electron microscope units worldwide. Containing high-quality representative images, this up-to-date text includes detailed information on the most important diagnostic applications of transmission electron microscopy as well as instructions for specific tissues and current basic preparative techniques.The book is relevant to trainee pathologists and practising pathologists who are expected to understand and evaluate/screen tissues by TEM. In addition, technical and scientific staff involved in tissue preparation and diagnostic tissue evaluation/screening by TEM will find this text useful. Inhaltsverzeichnis List of Contributors xvii Preface - Introduction xxi 1 Renal Disease 1 John W. Stirling and Alan Curry 1.1 The Role of Transmission Electron Microscopy (TEM) in Renal Diagnostics 1 1.2 Ultrastructural Evaluation and Interpretation 2 1.3 The Normal Glomerulus 3 1.3.1 The Glomerular Basement Membrane 4 1.4 Ultrastructural Diagnostic Features 5 1.4.1 Deposits: General Features 5 1.4.2 Granular and Amorphous Deposits 6 1.4.3 Organised Deposits: Fibrils and Tubules 7 1.4.4 Nonspecific Fibrils 11 1.4.5 General and Nonspecific Inclusions and Deposits 11 1.4.6 Fibrin 12 1.4.7 Tubuloreticular Bodies (Tubuloreticular Inclusions) 12 1.4.8 The Glomerular Basement Membrane 13 1.4.9 The Mesangial Matrix 14 1.4.10 Cellular Components of the Glomerulus 14 1.4.11 Parietal Epithelium 16 1.5 The Ultrastructural Pathology of the Major Glomerular Diseases 16 1.5.1 Diseases without, or with Only Minor, Structural GBM Changes 16 1.5.2 Diseases with Structural GBM ...
