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Informationen zum Autor Horacio D. Espinosa, Northwestern University, USA Horacio D. Espinosa is the James and Nancy Farley Professor of Mechanical Engineering at Northwestern University, USA. He is a member of the European Academy of Arts and Sciences, and Fellow of AAM, ASME, and SEM. He served as Editor-in-chief of the Journal of Experimental Mechanics and Associate Editor of the Journal of Applied Mechanics. Currently, he is a co-editor of the Wiley Book Series in Micro and Nanotechnologies and serves in several journal editorial boards. His research interests include biomimetics, size scale electro-mechanical properties of nanomaterials, NEMS, in-situ microscopy testing of nanostructures, and the development of microdevices for tip-based nanofabrication and single cell studies. Gang Bao, Georgia Institute of Technology, USA Gang Bao is Professor of Bioengineering at the Georgia Institute of Technology, USA. His research interests include biomolecular engineering, bionanotechnology, molecular imaging and molecular biomechanics. Klappentext Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book.Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies.Key features:* Provides an overview of recent advances in nano and cell mechanics.* Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena.* Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies.* Presents multiscale-multiphysics modeling and experimentation techniques.* Examines applications in materials, manufacturing, electronics, medicine and healthcare.Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics. Zusammenfassung Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Inhaltsverzeichnis About the Editors xiii List of Contributors xv Foreword xix Series Preface xxi Preface xxiii Part One BIOLOGICAL PHENOMENA 1 Cell-Receptor Interactions 3 David Lepzelter and Muhammad Zaman 1.1 Introduction 3 1.2 Mechanics of Integrins 4 1.3 Two-Dimensional Adhesion 7 1.4 Two-Dimensional Motility 9 1.5 Three-Dimensional Adhesion 11 1.6 Three-Dimensional Motility 12 1.7 Apoptosis and Survival Signaling 13 1.8...
List of contents
About the Editors xiii
List of Contributors xv
Foreword xix
Series Preface xxi
Preface xxiii
Part One BIOLOGICAL PHENOMENA
1 Cell-Receptor Interactions 3
David Lepzelter and Muhammad Zaman
1.1 Introduction 3
1.2 Mechanics of Integrins 4
1.3 Two-Dimensional Adhesion 7
1.4 Two-Dimensional Motility 9
1.5 Three-Dimensional Adhesion 11
1.6 Three-Dimensional Motility 12
1.7 Apoptosis and Survival Signaling 13
1.8 Cell Differentiation Signaling 13
1.9 Conclusions 14
References 15
2 Regulatory Mechanisms of Kinesin and Myosin Motor Proteins: Inspiration for Improved Control of Nanomachines 19
Sarah Rice
2.1 Introduction 19
2.2 Generalized Mechanism of Cytoskeletal Motors 19
2.3 Switch I: A Controller of Motor Protein and G Protein Activation 21
2.4 Calcium-Binding Regulators of Myosins and Kinesins 23
2.5 Phospho-Regulation of Kinesin and Myosin Motors 262.6 Cooperative Action of Kinesin and Myosin Motors as a "Regulator" 28
2.7 Conclusion 29
References 30
3 Neuromechanics: The Role of Tension in Neuronal Growth and Memory 35
Wylie W. Ahmed, Jagannathan Rajagopalan, Alireza Tofangchi, and Taher A. Saif
3.1 Introduction 35
3.2 Tension in Neuronal Growth 41
3.3 Tension in Neuron Function 48
3.4 Modeling the Mechanical Behavior of Axons 52
3.5 Outlook 58
References 58
Part Two NANOSCALE PHENOMENA
4 Fundamentals of Roughness-Induced Superhydrophobicity 65
Neelesh A. Patankar
4.1 Background and Motivation 65
4.2 Thermodynamic Analysis: Classical Problem (Hydrophobic to Superhydrophobic) 67
4.3 Thermodynamic Analysis: Classical Problem (Hydrophilic to Superhydrophobic) 84
4.4 Thermodynamic Analysis: Vapor Stabilization 86
4.5 Applications and Future Challenges 90
Acknowledgments 91
References 91
5 Multiscale Experimental Mechanics of Hierarchical Carbon-Based Materials 95
Horacio D. Espinosa, Tobin Filleter, and Mohammad Naraghi
5.1 Introduction 95
5.2 Multiscale Experimental Tools 97
5.3 Hierarchical Carbon-Based Materials 106
5.4 Concluding Remarks 120
References 123
6 Mechanics of Nanotwinned Hierarchical Metals 129
Xiaoyan Li and Huajian Gao
6.1 Introduction and Overview 129
6.2 Microstructural Characterization and Mechanical Properties of Nanotwinned Materials 134
6.3 Deformation Mechanisms in Nanotwinned Metals 145
6.4 Concluding Remarks 156
References 157
7 Size-Dependent Strength in Single-Crystalline Metallic Nanostructures 163
Julia R. Greer
7.1 Introduction 163
7.2 Background 164
7.3 Sample Fabrication 170
7.4 Uniaxial Deformation Experiments 175
7.5 Discussion and Outlook on Size-Dependent Strength in Single-Crystalline Metals 178
7.6 Conclusions and Outlook 184
References 185
Part Three EXPERIMENTATION
8 In-Situ TEM Electromechanical Testing of Nanowires and Nanotubes 193
Horacio D. Espinosa, Rodrigo A. Bernal, and Tobin Filleter
8.1 Introduction 193
8.2 In-Situ TEM Experimental Methods 197
8.3 Capabilities of In-Situ TEM Applied to One-Dimensional Nanostructures 212
8.4 Summary and Outlook 220
Acknowledgments 221
References 221
9 Engineering Nano-Probes for Live-Cell Imaging of Gene Expression 227
Gang Bao, Brian Wile, a
