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Ever since Richard Bright discovered the link between kidney disease and cardiac hypertrophy inhispioneeringworkin 1827,thefieldofrenovascularandrenal parenchy matous hypertension has been a transatlantic adventure. Towards the end of the nine teenth century, Tigerstedt and Bergman discovered that the kidneys contain a factor whichraisedbloodpressurewheninjected intointactanimals. Theynamedthesubstance renin, which is now known as the crucial enzyme activating the angiotensin aldosterone system, which is so pertinent in the regulation of blood pressure and kidney function. After this crucial European contribution to the field, Harry Goldblatt at the Cleveland Clinic demonstrated in his classical experiments that reduction in renal blood flow, by placing a clamp at the major renal artery, could induce sustained hypertension. These discoveries established the role of the kidney in certain forms of hypertension which are now classified as renovascular and renal parenchymatous hypertension. These fundamental concepts suggested - based on experimental evidence - that restoration of blood flow or nephrectomy in unilateral parenchymatous disease would lead to blood pressure normalization in these patients. Indeed, as early as the first half of this century, a report appeared demonstrating blood pressure normalization in a child with fibromusculardisplasiaofthe right renalartery after nephrectomy. Advances in surgical techniques later allowed reconstructive renovascular surgery and therefore a more appropriate form of therapy of the disease. In the late seventies Andreas Grtinzig initiated another European contribution to renovascular hypertension by introducting the procedure of percuteaneous transluminal angioplasty, an elegant catheter technique allowing non-surgical therapy of renovascular disease.
List of contents
The Kidney and Hypertension.- The Kidney and Regulation of Blood Pressure.- Glomerular Hemodynamics and Experimental Renal Injury.- Sodium, the Kidney, and Hypertension.- Epidemiology and Clinical Importance of Renovascular and Renal Parenchymatous Hypertension.- Renovascular Hypertension.- Pathology and Pathogenesis of Renovascular Hypertension.- Mechanisms of Experimental and Human Renovascular Hypertension.- Vascular Renin-Angiotensin System and Renovascular Hypertension.- Angiographical Diagnosis of Renovascular (and Renal Parenchymatous) Hypertension.- Radioisotope Renography.- Noninvasive Assessment of Human Renal Blood Flow by Ultrasonic Doppler Flowmetry.- The Renin-Sodium Profile and the Captopril Test as Tools for the Diagnosis of Renovascular Hypertension.- Surgical Management of Main Renal Artery Disease.- Surgical Management of Branch Renal Arterial Disease.- Percutaneous Transluminal Angioplasty: Technique, Results and Complications.- Long-Term Results of Percutaneous Transluminal Renal Angioplasty.- Medical Therapy of Renovascular and Renal Parenchymatous Hypertension: General Principles.- Medical Therapy in Renovascular Hypertension: Angiotensin-Converting Enzyme Inhibitors.- Renal Parenchymatous Hypertension.- The Kidney as Target Organ in Hypertension.- Imaging of Renal Parenchymatous Hypertension.- Sonographic Diagnosis of Renal Hypertension.- Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy of the Kidneys.- Bilateral Kidney Disease and Hypertension.- Diabetes, the Kidney, and Hypertension.- Renal Transplantation, Blood Pressure, and Hypertension.- Cyclosporine, Hypertension, and the Kidney.- Unilateral (Curable) Renal Parenchymatous Hypertension.- Surgical Treatment of Renal Parenchymatous Hypertension.
About the author
Prof. Dr. med. Thomas F. Lüscher ist Direktor der Klinik für Kardiologie am Universitätsspital Zürich.
