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Aneuploidy - the greatest genetic affliction of man - has
its origin in manycellular processes. Its forerunner,
chromosome non-disjunction, can result from malfunction of
one of many processes involved in faithful segregation of
chromosomes during mitosis or meiosis.
Experts on chromosome biology,centromere, kinetochore,
microtubules, spindle apparatus, biochemistry of mitosis and
meiosis, developmental biology, and environmental
mutagenesis discuss basic and applied aspects of how
chromosomes malsegregate and how aneuplody originates.
The most recent techniques employed to study chromosome
segregation and also methods to determine aneugenic
chemicals are described.
List of contents
Chromosome Segregation and Aneuploidy.- Structure of the Mammalian Centromere.- Properties of CENP-B and Its Target Sequence in Satellite DNA.- The Minor Satellite of Mouse and the Centromere.- Centromere Organization in Man and Mouse.- New Tools for the Study of Chromosome Segregation and Aneuploidy at the Molecular Level.- Premature Centromere Division and Other Centromeric Misbehaviour.- Genetic Approaches for Identifying Kinetochore Components in Saccharomyces Cerevisiae.- Cell Cycle Regulation of Centromere Function in Saccharomyces Cerevisiae.- Sensing DNA Damage: a Role for Chromosome Communication in Aneuploidy Induction.- The Acquisition and Association of TG1-3 Single-Strand Tails During Replication of Saccharomyces Telomeres.- Transposition as a Mechanism for Maintaining Telomere Length in Drosophila.- Molecular Features of Heterochromatin Condensation.- RCC1-Ran-RanGAP Signal for Initiation of Mitosis.- Implications of Cell Cycle Disturbances for Meiotic Aneuploidy: Studies on a Mouse Model System.- Morphogenesis of the Mitotic and Meiotic Spindle: Conclusions Obtained from One System Are Not Necessarily Applicable to the Other.- A Genetic Analysis of Microtubule Assembly and Function in Yeast.- The Events and Regulation of Anaphase Onset.- Microtubule Converging Centers - Implications for Microtubule Dynamics in Higher Plants.- Development of Kinetochores During Early Mitosis in HeLa Cells and the Stability of a Trilaminar Kinetochore Structure.- Are Topoisomerases Required for Mammalian Chromosome Segregation?.- Possible Targets for the Aneugenic Activity of Alkylating Agents.- The Relationship Between Chemically-Induced Meiotic Delay and Aneuploidy in Mouse Oocytes and Zygotes.- Correlation Between Induction of Meiotic Delay and Aneuploidy in MaleMouse Germ Cells.- Analysis of Micronuclei and Microtubule Arrangement to Identify Aneuploidy-Inducing Agents in Cultured Mammalian Cells.- Effects of Antitopoisomerase Drugs on Chromosome Recombination and Segregation in Grasshopper.- Disruption of Centromere Function by 2-Aminopurine.- Induction of Mitotic Aneuploidy in Lower Eukaryotes.- In Vivo Assay for Detection and Evaluation of Aneugens.- Multicolor Fluorescence in situ Hybridization with Centromeric DNA Probes as a New Approach to Distinguish Chromosome Breakage from Aneuploidy in Interphase Cells and Micronuclei.- The Detection, Definition and Regulation of Aneugenic Chemicals.
