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Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. A collection of distinguished authors draws together the underlying mechanisms involved in the process of transcription. This includes RNA polymerase function and its interaction with promoter sequences, and the structures of the various components on the transcriptional machinery. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.
List of contents
Fundamental Aspects of T7 RNA Polymerase Structure and Mechanism.- Transcription by T7 RNA Polymerase.- Pribnow Box Recognition and Melting by Escherichia coli RNA Polymerase.- Extended -10 Promoters.- Promoter Selectivity Control of RNA Polymerase.- The Effect of High Pressure on Transcription and on the Structure and Activity of E. coli RNA Polymerase.- Ribosomal RNA Promoter-RNA Polymerase Interactions and rRNA Transcription in Escherichia coli.- Synergistic Activation of Transcription in E. coli.- Indirect Effects of DNA Sequence on Transcriptional Activation by Prokaryotic DNA Binding Proteins.- Transcriptional Activation by a Topologically Linkable Protein: Forging a Connection Between Replication and Gene Activity.- Translocation of DNA-Dependent E. coli RNA Polymerase During RNA Synthesis.- Stabilisation of DNA Microloops by FIS - A Mechanism for Torsional Transmission in Transcription Activation and DNA Inversion.- Transcription and DNA Topology in Eubacteria.- Modeling Large DNA Molecules: Long-Range Interactions and Regulation of Transcription.- Structure of the POU Domain.- Structural Studies of Eukaryotic Transcription Initiation.- Understanding SRY-Related 46X,Y Sex Reversal at the Atomic Level.- Nucleosomes and Transcription.- Antirepression, Potentiation and Activation of Promoters in Reconstituted Chromatin.- Acetylation, Activation and Toxicity; the Role of ADA/GCN5 Complex in Transcription.
Report
"The editors are to be congratulated in assembling an excellent collection of contributions from very eminent authors. This book will make a splendid addition to the shelves of those interested in the biophysics, biochemistry and structural biology of transcription and its regulation." Heredity
