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Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
List of contents
Bovine Spongiform Encephalopathy.- Classical and Atypical Scrapie in Sheep and Goats.- Sporadic Human Prion Disease.- Environmentally-acquired Transmissible Spongiform.- Prions in the Environment.- The Spectrum of Tau Pathology in Human Prion Disease.- Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion.- Species Barriers in Prion Disease.- Transgenic Mice Modelling.- Prion Transmission Studies in Transgenic Mice.- Alternative Models of Prion Diseases.- Diagnosis of Prion Disease: Conventional Approaches.- Quaking-induced Conversion (QuIC) Assays for the Detection and Diagnosis of Prion Diseases.- Overview on Treatment of Prion Diseases and Decontamination of Prions.- Immunomodulation.
Summary
Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
