Read more
The genomic 'golden age' has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of state of the art basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.
List of contents
Genomics and Evolution of the TRIM Gene Family.- The TRIpartite Motif: Structure and Function.- TRIM Proteins as RING Finger E3 Ubiquitin Ligases.- PML Nuclear Bodies and Other TRIM-Defined Subcellular Compartments.- TRIM Involvement in Transcriptional Regulation.- TRIM Proteins in Cancer.- TRIM Proteins and the Innate Immune Response to Viruses.- The Microtubule-Associated C-I Subfamily of Trim Proteins and the Regulation of Polarized Cell Responses.- MuRFs: Specialized Members of the TRIM/RBCC Family with Roles in the Regulation of the Trophic State of Muscle and Its Metabolism.- TRIM Proteins in Development.
About the author
Germana Meroni is a graduate of the University of Milan, Italy. She was a post‑graduate fellow at the Department of Biotechnology of the San Raffaele Hospital in Milan, Italy, and then post‑doctoral fellow at the Department of Human and Molecular Genetics of Baylor College of Medicine, Houston, TX (USA). She established her research group at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples and then moved as leader of the Functional Genomics Laboratory at the Cluster in Biomedicine within AREA Science Park in Trieste, Italy. Her main research interest is the genetics and biochemistry of the Tripartite Motif family in health and disease.
Summary
The genomic ‘golden age’ has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.
