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An intimate relation between hormones and lipoprotein metabolism has been known for a long time especially from hormone-deficiency or -overproduction syndromes. The mechanisms through which hormones influence lipid metabolism have become a field of major interest in sci ence. The more we learn about cellular hormonal actions the better we understand regulatory processes and phenomena occuring in patients. The present book summarizes data discussed at an International Meet ing at Marburg, Germany, on "Hormones in Lipoprotein Metabolism". It was an attempt to pull together knowledge in basic science from the mode of action of hormones all the way to clinical appearance of hor monal disorders involving lipoprotein metabolism. Thus data on molec ular biology, on hormonal regulation of apolipoprotein synthesis, on lipoprotein receptors and enzyme induction are discussed together with the large field of oral contraceptive use, postmenopausal estrogen sub stitution, lipid disorders in diabetes mellitus, in thyroid dysfunction, in adrenal insufficiency and in glucocorticoid application. We are aware of the fact that such an overview cannot be complete but should serve as a collection of data and ideas for those interested in hormonal regulation of lipid metabolism. We thank all authors for taking an extra effort in writing up their presentations and thus making this edition possible. We also thank Bristol-Myers-Squibb for generous support of the meeting and of the final publication. Marburg, Germany ARMIN STEINMETZ JURGEN SCHNEIDER HANS KAFFARNIK Contents Molecular Biology Chairmen: D. J. Rader, A.
List of contents
Molecular Biology.- Interaction of Steroid Hormone Receptors with DNA.- Hormonal Control of Genes Involved in Lipoprotein Metabolism in the Rat.- Apolipoprotein B mRNA Editing: Modulation and Clinical Implications.- Insulin, Diabetes mellitus, Obesity.- Hormonal Regulation of Lipoprotein Metabolism in Obesity.- Lipoproteins in Patients with NIDDM: Effects of Different Therapeutic Approaches.- Postprandial Course of Triglycerides and the Atherogenic Lipoprotein Particle "IDL" in Type 2 Diabetics with Normal Fasting Values.- Differences Between Basal and Postprandial Circadian Variation of Insulin Sensitivity in Healthy Subjects and Type 1 Diabetics.- Effect of Fish Oil Concentrate on the Lipoprotein Profile in Patients Suffering from Diabetes mellitus Type II.- Sex-Hormones - Mechanism of Action, Epidemiology.- Pharmacology of Female Sex Hormones with Respect to Lipid and Lipoprotein Metabolism.- Why Women Live Longer Than Men (or Why Can't a Man be More Like a Woman?).- Induction of the Hepatic Uptake of Lipoproteins by Estrogen.- Changes in Serum Lipoprotein Profiles During Puberty - A Longitudinal Study of Dresden Schoolchildren.- Coronary Risk in Women: Potential Role of Age, Lipoproteins, Haemostasis, and Hormones.- Different Lipoprotein Patterns in Men and Women Examined by Coronary Angiography.- Sex-Hormones - Action on Plasma Lipoproteins.- Influence of Oral and Percutaneous Estrogen Therapy on the Lipoprotein Particle Profile of Postmenopausal Women.- Effects of Different Oral Contraceptives on Apolipoprotein E.- Effects of a New Oral Contraceptive Containing Ethinyl Estradiol Desogestrel on Plasma Lipoproteins and Apolipoproteins.- Anabolic Steroids do not Change mRNA Levels and Protein Secretion of Apolipoprotein A-I and B-100 in HepG2 Cells.- VLDLApoB-100 and ApoE Metabolism in Male Female Subjects Utilizing the Stable Isotope Technique.- Testosterone Lowers Serum Concentrations of Lipoprotein Lp(a).- Hormones other than Sex Steroids.- The Role and Mechanism of Glucocorticoids on the Modulation of Lipid and Lipoprotein Metabolism.- Lipids and Lipoproteins in Thyroid Dysfunction.- Incidence and Treatment of Hyperlipidemia in Primary and Secondary Adrenal Insufficiency.- Cholesterol Lowering Effect of Simvastatin in Patients with Normal and Impaired Renal Function.- Determinants for Coronary Atherosclerosis Regression. The Marburg Lipid Intervention Trial.- Medical Imaging System and Their Use in the Diagnosis of Cerebral Attacks Caused by Metabolic Disorders.
About the author
Dr. Jürgen Schneider, geboren 1934 in Frankfurt am Main, Dipl.-Bauingenieur, verheiratet, zwei Kinder. Bis 1982 als Geschäftsführer in der väterlichen Baufirma tätig, danach Aufbau eines Milliardenimperiums als privater Bauinvestor. 1994 Flucht nach Miami und Zusammenbruch der Firma, 1997 Strafprozess wegen Betrugs, Ende 1999 nach Verbüßung von zwei Dritteln seiner Strafe entlassen.
