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Informationen zum Autor Tracey Lamb is the editor of Immunity to Parasitic Infection , published by Wiley. Klappentext Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. This book examines current knowledge about immune responses to parasitic infections affecting humans, including interactions that occur during co-infections, and how immune responses may be manipulated to develop therapeutic interventions against parasitic infection.For easy reference, the most commonly studied parasites are examined in individual chapters written by investigators at the forefront of their field. An overview of the immune system, as well as introductions to protozoan and helminth parasites, is included to guide background reading. A historical perspective of the field of immunoparasitology acknowledges the contributions of investigators who have been instrumental in developing this field of research. Zusammenfassung Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. Inhaltsverzeichnis List of Contributors xiii Introduction: Immunoparasitology: The Making of a Modern Immunological science 1 Alan Sher Section 1 1 Notes on the Immune System 15 Tracey J. Lamb 1.1 The immune system 15 1.2 Innate immune processes 17 1.3 The complement cascade 19 1.4 Innate recognition 20 1.5 Pattern recognition receptors 21 1.6 Innate immune cells 23 1.7 Communication in the immune system 31 1.8 Adaptive immunity 31 1.9 The role of theMHC in the immune response 34 1.10 T cell activation and cellular-mediated immunity 36 1.11 B cells and the humoral response 43 1.12 Cell trafficking around the body 49 1.13 Cellular immune effector mechanisms 50 1.14 Hypersensitivity reactions 52 References for further reading 54 Section 2 2 Introduction to Protozoan Infections 61 David B. Guiliano and Tracey J. Lamb 2.1 The protozoa 61 2.2 Amoebozoa 62 2.3 Excavata 67 2.4 Harosa 75 2.5 Protozoa that are now fungi 81 2.6 Taxonomy and the evolution of the parasitic protozoa 82 2.7 Genomic and post genomic exploration of protozoan biology 83 2.8 Summary 87 2.9 General information on protozoa 88 References for further reading 88 3 Apicomplexa:Malaria 91 Tracey J. Lamb and Francis M. Ndung'u 3.1 Malaria 91 3.2 Recognition ofmalaria parasites 94 3.3 Innate effector mechanisms 95 3.4 Adaptive immunity 98 3.5 Memory responses 101 3.6 Immune evasion 101 3.7 Immunopathology 103 References for further reading 105 4 Apicomplexa: Toxoplasma gondii 107 EmmaWilson 4.1 Introduction 107 4.2 Life cycle and pathogenesis 107 4.3 Innate immune responses 111 4.4 Evasion strategies 113 4.5 Adaptive immune responses 115 4.6 CNS infection 117 4.7 Conclusions 118 References for further reading 118 5 Apicomplexa: Cryptosporidium 121 Jan R. Mead andMichael J. Arrowood 5.1 Life cycle 122 5.2 Clinical presentation 123 5.3 General immune responses in cryptosporidiosis 124 5.4 Innate effector mechanisms 125 5.5 Adaptive immunity 127 5.6 Memory responses 131...
