Immunity to Parasitic Infection

Informationen zum Autor Tracey Lamb is the editor of Immunity to Parasitic Infection , published by Wiley. Klappentext Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. This book examines current knowledge about immune responses to parasitic infections affecting humans, including interactions that occur during co-infections, and how immune responses may be manipulated to develop therapeutic interventions against parasitic infection.For easy reference, the most commonly studied parasites are examined in individual chapters written by investigators at the forefront of their field. An overview of the immune system, as well as introductions to protozoan and helminth parasites, is included to guide background reading. A historical perspective of the field of immunoparasitology acknowledges the contributions of investigators who have been instrumental in developing this field of research. Zusammenfassung Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. Inhaltsverzeichnis List of Contributors xiii Introduction: Immunoparasitology: The Making of a Modern Immunological science 1 Alan Sher Section 1 1 Notes on the Immune System 15 Tracey J. Lamb 1.1 The immune system 15 1.2 Innate immune processes 17 1.3 The complement cascade 19 1.4 Innate recognition 20 1.5 Pattern recognition receptors 21 1.6 Innate immune cells 23 1.7 Communication in the immune system 31 1.8 Adaptive immunity 31 1.9 The role of theMHC in the immune response 34 1.10 T cell activation and cellular-mediated immunity 36 1.11 B cells and the humoral response 43 1.12 Cell trafficking around the body 49 1.13 Cellular immune effector mechanisms 50 1.14 Hypersensitivity reactions 52 References for further reading 54 Section 2 2 Introduction to Protozoan Infections 61 David B. Guiliano and Tracey J. Lamb 2.1 The protozoa 61 2.2 Amoebozoa 62 2.3 Excavata 67 2.4 Harosa 75 2.5 Protozoa that are now fungi 81 2.6 Taxonomy and the evolution of the parasitic protozoa 82 2.7 Genomic and post genomic exploration of protozoan biology 83 2.8 Summary 87 2.9 General information on protozoa 88 References for further reading 88 3 Apicomplexa:Malaria 91 Tracey J. Lamb and Francis M. Ndung'u 3.1 Malaria 91 3.2 Recognition ofmalaria parasites 94 3.3 Innate effector mechanisms 95 3.4 Adaptive immunity 98 3.5 Memory responses 101 3.6 Immune evasion 101 3.7 Immunopathology 103 References for further reading 105 4 Apicomplexa: Toxoplasma gondii 107 EmmaWilson 4.1 Introduction 107 4.2 Life cycle and pathogenesis 107 4.3 Innate immune responses 111 4.4 Evasion strategies 113 4.5 Adaptive immune responses 115 4.6 CNS infection 117 4.7 Conclusions 118 References for further reading 118 5 Apicomplexa: Cryptosporidium 121 Jan R. Mead andMichael J. Arrowood 5.1 Life cycle 122 5.2 Clinical presentation 123 5.3 General immune responses in cryptosporidiosis 124 5.4 Innate effector mechanisms 125 5.5 Adaptive immunity 127 5.6 Memory responses 131...

List of contents

List of Contributors xiii
 
Introduction: Immunoparasitology: The Making of a Modern Immunological science 1
Alan Sher
 
Section 1
 
1 Notes on the Immune System 15
Tracey J. Lamb
 
References for further reading 54
 
Section 2
 
2 Introduction to Protozoan Infections 61
David B. Guiliano and Tracey J. Lamb
 
References for further reading 88
 
3 Apicomplexa:Malaria 91
Tracey J. Lamb and Francis M. Ndung'u
 
References for further reading 105
 
4 Apicomplexa: Toxoplasma gondii 107
EmmaWilson
 
References for further reading 118
 
5 Apicomplexa: Cryptosporidium 121
Jan R. Mead andMichael J. Arrowood
 
References for further reading 134
 
6 Diplomonadida: Giardia 139
Steven Singer
 
References for further reading 150
 
7 Kinetoplastids: Leishmania 153
IngridM¨ uller and Pascale Kropf
 
References for further reading 164
 
8 Kinetoplastids: Trypanosomes 165
Jeremy Sternberg
 
References for further reading 176
 
9 Kinetoplastids: Trypanosoma cruzi (Chagas disease) 179
Rick Tarleton
 
References for further reading 189
 
Section 3
 
10 Introduction to Helminth Infections 195
David B. Guiliano
 
References for further reading 213
 
11 Nematoda: Filarial Nematodes 217
Sabine Specht and Achim Hoerauf
 
References for further reading 229
 
12 Nematoda: Ascaris lumbricoides 231
Christina Dold
 
References for further reading 243
 
13 Nematoda: Hookworms 247
Soraya Gaze, HenryMcSorley and Alex Loukas
 
References for further reading 259
 
14 Nematoda: Trichuris 263
Colby Zaph
 
References for further reading 271
 
15 Nematoda: Trichinella 275
Judith A. Appleton, Lisa K. Blum and Nebiat G. Gebreselassie
 
References for further reading 284
 
16 Trematoda: Schistosomes 287
Mark Wilson
 
References for further reading 303
 
17 Cestoda: Tapeworm Infection 307
C´esar A. Terrazas,Miriam Rodr´?guez-Sosa and Luis I. Terrazas
 
References for further reading 320
 
Section 4
 
18 Co-infection: Immunological Considerations 325
Joanne Lello
 
References for further reading 333
 
19 HIV and Malaria Co-infection 335
Aubrey Cunnington and EleanorM. Riley
 
References for further reading 351
 
20 HIV and Leishmania Co-infection 353
JavierMoreno
 
References for further reading 359
 
21 Gastrointestinal Nematodes and Malaria 361
Mathieu Nacher
 
References for further reading 372
 
22 Malaria and Schistosomes 375
ShonaWilson and Jamal Khalife
 
References for further reading 385
 
Section 5
 
23 Hygiene and Other Early Childhood Influences on the Subsequent Function of the Immune System 391
Graham A.W. Rook
 
References for further reading 400
 
24 Nematodes as Therapeutic Organisms 401
William Harnett andMargaretM. Harnett
 
References for further reading 413
 
AlbertoMoreno
 
References for further reading 429
 
Yasuyuki Goto and Steven G. Reed
 
References for further reading 438
 
Brent Schneider,Maria Victoria Periago and Jeffrey M. Bethony
 
References for further reading 456
 
Sara Lustigman
 
References for further reading 468
 
Abbreviations 471
 
Glossary 479
 
Index 493

Product details

• Authors: T Lamb, Tracey Lamb, Tracey (University of Reading) Lamb, Lamb Tracey
• Assisted by: Tracey Lamb (Editor), Lamb Tracey (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 14.09.2012
• EAN: 9780470972472
• ISBN: 978-0-470-97247-2
• No. of pages: 520
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; Medizin, Immunologie, Immunology, Life Sciences, Biowissenschaften, Medical Science, Klinische Mikrobiologie, Clinical Microbiology, Infektionsabwehr