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Informationen zum Autor Dr PJ Cullen is a lecturer in?the Faculty of Engineering at the University of New South Wales. His current research interests include rheology, mixing, chemical imaging and non-thermal plasmas for biological applications in food. He has published over 35 journal papers, 15 book chapters and edited 1 book on food mixing. Professor Rodolfo J. Romañach is Professor of Chemistry at the University of Puerto Rico. He has over 20 years of experience in vibrational spectroscopy, and worked in Puerto Rico's pharmaceutical industry for 12 years prior to joining the UPR-Mayagüez faculty. In the pharmaceutical industry he worked extensively in assay and cleaning validation, and in providing analytical support for API and pharmaceutical process related problems. Professor Nicolas Abatzaglou is Director of the?Chemical Engineering and Biotechnological Engineering Department and Holder of the Pfizer Chair: PAT in Pharmaceutical Engineering at the Universite de Sherbrooke, Canada. He is the current recipient of Quebec's Minister of Education (MELS Chantier II) Fellowship award for his excellence in research and teaching. Professor Chris Rielly is Head of the Department of Chemical Engineering at Loughborough University. He has taught chemical engineering for over 20 years at Cambridge and Loughborough Universities and is a Fellow of the Institution of Chemical Engineers with more than 20 years of experience working in experimental and computational fluid mechanics. His interests include multi-phase flow, mass transfer and turbulent mixing in chemical processing equipment. He has served on the Scientific Committees of the European Conference on Mixing, the International Conference on Gas-Liquid-Solid Reaction Engineering and the Process Innovation and Intensification Conference. He is an academic consultant to BHR Group's Fluid Mixing Processes Industrial Consortium and Chairman of the IChemE's Fluid Mixing Subject Group. He has previously edited books. Klappentext Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering. Zusammenfassung Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. Inhaltsverzeichnis Contributor List xv Preface xvii Part I Fundamentals of Mixing 1 1 Mixing Theory 3 Chris D. Rielly 1.1 Introduction 3 1.2 Describing Mixtures 5 1.3 Scale of Scrutiny 6 1.4 Quantifying Mixedness for Coarse and Fine¿Grained Mixtures 8 1.4.1 Coarse and Fine¿Grained Mixtures 8 1.4.2 Scale and Intensity of Segregation 9 1.5 Determining the End¿Point of Mixing: Comparison of Mixing Indices 15 1.6 Continuous Flow Mixers 19 1.6.1 Idealized Mixing Patterns 19 1.6.2 Residence Time Distributions 21 1.6.3 Back¿Mixing and Filtering of Disturbances Using a CSTR 23 References 24 2 Turbulent Mixing Fundamentals 27 Suzanne M. Kresta 2.1 Introduction 27 2.2 The Velocity Field and Turbulence 28 2.3 Circulation and MacröMixing 29 2.4 Fully Turbulent Limits and the Scaling of Turbulence 32 2.5 The Spectrum of Turbulent Length Scales, Injection of a Scalar (Either Reagent or Additive) and the Macrö, Mesö and Mi...
