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Retinal and choroidal angiogenesis are the leading causes of irreversible vision loss in developed countries. For this reason, ocular angiogenesis is an intensely studied process, and the field is advancing at an astounding pace. It has become increasingly difficult to manage the vast amount of information generated by the growing group of interested investigators, thus a resource is needed that distills and summarizes our progress to date.
Retinal and Choroidal Angiogenesis provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Renowned academic scientists, pharmaceutical scientists, and clinician-scientists have contributed chapters identifying the cellular and molecular mechanisms of retinal and choroidal angiogenesis; defining animal models of these pathologic processes; or describing the application of current tools, techniques, and theories to disease pathogenesis in humans suffering from conditions characterized by ocular angiogenesis. Additionally, novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye.
Retinal and Choroidal Angiogenesis emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance. The result is a reference work appealing to ophthalmologists interested in clinical applications, as well as to basic scientists interested in the cellular and molecular mechanisms of angiogenesis, both in the context of ocular and non-ocular conditions.
List of contents
Angiogenesis Study Models.- Cellular and Molecular Mechanisms of Retinal Angiogenesis.- Animal Models of Choroidal Neovascularization.- Rodent Models of Oxygen-Induced Retinopathy.- Animal Models of Diabetic Retinopathy.- Neovascularization in Models of Branch Retinal Vein Occlusion.- Molecular Characterization.- Vasculogenesis and Angiogenesis in Formation of the Human Retinal Vasculature.- IGF-1 and Retinopathy.- Hypoxia and Retinal Neovascularization.- Hypoxia Inducible Factor-1 and VEGF Induction.- The Role of Protein Kinase C in Diabetic Retinal Vascular Abnormalities.- Eph Receptor Tyrosine Kinases: Modulators of Angiogenesis.- Adenosine in Retinal Vasculogenesis and Angiogenesis in Oxygen-Induced Retinopathy.- The Regulation of Retinal Angiogenesis by Cyclooxygenase and the Prostanoids.- Extracellular Proteinases in Ocular Angiogenesis.- Oxygen-Independent Angiogenic Stimuli.- Growth Factor Synergy in Angiogenesis.- Pigment Epithelium-Derived Factor and Angiogenesis.- Circulating Endothelial Progenitor Cells and Adult Vasculogenesis.- Applications to Clinical Conditions.- Retinopathy of Prematurity.- Angiogenesis in Sickle Cell Retinopathy.- Diabetic Retinopathy.- Systems for Drug Delivery to the Posterior Segment of the Eye.- Novel Therapeutic Strategies For Posterior Segment Neovascularization.- Choroidal Neovascularization in Age-Related Macular Degeneration-From Mice to Man.
Summary
Retinal and choroidal angiogenesis are the leading causes of irreversible vision loss in developed countries. For this reason, ocular angiogenesis is an intensely studied process, and the field is advancing at an astounding pace. It has become increasingly difficult to manage the vast amount of information generated by the growing group of interested investigators, thus a resource is needed that distills and summarizes our progress to date.
Retinal and Choroidal Angiogenesis provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Renowned academic scientists, pharmaceutical scientists, and clinician-scientists have contributed chapters identifying the cellular and molecular mechanisms of retinal and choroidal angiogenesis; defining animal models of these pathologic processes; or describing the application of current tools, techniques, and theories to disease pathogenesis in humans suffering from conditions characterized by ocular angiogenesis. Additionally, novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye.
Retinal and Choroidal Angiogenesis emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance. The result is a reference work appealing to ophthalmologists interested in clinical applications, as well as to basic scientists interested in the cellular and molecular mechanisms of angiogenesis, both in the context of ocular and non-ocular conditions.
