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In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
List of contents
Historical Perspectives.- Anti-Inflammatory Drugs in the 21st Century.- Inflammatory Mechanisms of Pathogenesis.- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus.- Obesity, Inflammation, and Vascular Disease.- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer.- Role of COX-2 in Inflammatory and Degenerative Brain Diseases.- Inflammation and Cardiovascular Disease: The Coxib Controversy.- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors.- COX-2 Inhibitors And Cardiovascular Risk.- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib.- Cox-2 Blockade in Cancer Prevention and Therapy.- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade.- Strategies for Colon Cancer Prevention.- Inflammation and Neurodegenerative Disease.- NSAIDs for the Chemoprevention of Alzheimer's Disease.- Inflammation in parkinson's disease.- Nutrition, Inflammation and Chronic Disease.- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases.- Nutritional Intervention in Brain Aging.
Summary
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.
Additional text
From the reviews:
“This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. … Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. … It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library.” (Vladimir N. Despotovic, Doody’s Review Service, February, 2010)
Report
From the reviews: "This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. ... Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. ... It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library." (Vladimir N. Despotovic, Doody's Review Service, February, 2010)
