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Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.
Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.
List of contents
Introduction.- Candidate Gene Association Studies in Stroke.- Genome-Wide Association Studies (GWAS).- The Genetics of Cerebral Aneurysms and Other Vascular Malformations.- Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy.- Clinicogenetic and Pathologic Characteristics of CADASIL.- Monogenic Disorder: Fabry Disease.- Stroke-like Episodes in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS).- Genetics of Sickle Cell Disease and Stroke.- Other Monogenetic Stroke Disorders.- White Matter Disease.- Genetics of Carotid Disease.- Genetics of Cervical Artery Dissection.- Stroke Pharmacogenetics.- Ethical Issues in the Genetics of Complex Disorders.
About the author
Pankaj Sharma, MD, PhD, FRCP
Reader & Consultant Neurologist
Imperial College London & Hammersmith Hospitals
London, UK
James F. Meschia, MD
Chair, Department of Neurology
Mayo Clinic Florida
Jacksonville, Florida, USA
Summary
Over the last decade there has been a big increase in our understanding of the genetic basis of common disorders such as stroke. This book provides the reader with an overall understanding of the genetics of complex diseases by using stroke as a paradigm.
Report
From the reviews:
"This text reviews genetics of cerebrovascular diseases ... . It covers the pathophysiology of occlusive small vessel disease and arteriopathies. It covers Fabry's Disease, Amyloidosis, MELAS, etc., etc. It covers the imaging, pathophysiology, treatment, and complications for ischemia and hemorrhaging. I recommend this text for neurosurgeons, neurologists, physiologists, genetic investigators, and those with an interest in vascular diseases affecting the cerebrum." (Joseph J. Grenier, Amazon.com, May, 2014)
