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Informationen zum Autor JEROLD CHUN, MD, PhD , is a Professor at The Scripps Research Institute in La Jolla, California, and is a pioneer in the field of lysophospholipid signaling. Klappentext The current state of the science supporting new research in lysophospholipidsThe study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports-ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems-have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.Lysophospholipid Receptors is divided into three sections:* Receptors and other possible effectors* Enzymes* Physiology and pathophysiologyWithin each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field. Zusammenfassung This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and that has important, natural roles in the body, being essential for normal reproduction, development, maturation and life. Inhaltsverzeichnis PREFACE ix CONTRIBUTORS xi 1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1 Hope Mirendil, Mu-En Lin, and Jerold Chun 2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41 Bongnam Jung and Timothy Hla 3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED FIBROBLASTS 61 Catelijne Stortelers and Wouter H. Moolenaar 4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE (S1P) 71 Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel 5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE KINASE-G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85 Nigel J. Pyne and Susan Pyne 6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE FUNCTIONS 103 Hiroshi Yukiura and Junken Aoki 7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121 Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu 8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY 137 Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown, and Walter A. Shaw 9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153 Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson 10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE TRANSPORTERS 185 Atsuo Kawahara and Tsuyoshi Nishi 11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS 201 Ganesh Venkat...
