Vaccinology - Principles and Practice

Informationen zum Autor W. John W. Morrow , Seattle, Washington, USA Nadeem A. Sheikh , Dendreon, Inc., Seattle, Washington, USA Clint S. Schmidt , NovaDigm Therapeutics, Inc., Grand Forks, North Dakota, USA D. Huw Davies , University of California at Irvine, USA Klappentext Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.* Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application* Includes evaluation of vaccine efficacy and safety* Details clinical trial design, including regulatory requirements* Discusses the emerging field of active cellular immunotherapyVaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines. Zusammenfassung This book addresses a profound deficiency in the field of vaccine research and development, namely the lack of a single volume describing the design and construction of vaccine strategies from first principles to implementation. Inhaltsverzeichnis List of Contributors viii Preface xii Part 1 Introduction 1 Concept and Scope of Modern Vaccines 3 D. Huw Davies, Clint S. Schmidt, & Nadeem A. Sheikh Part 2 Principles of Vaccine Design 2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants 15 Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, & Volker Gerdts 3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules 29 Antony N. Antoniou, Izabela Lenart, David B. Guiliano, & Simon J. Powis 4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design 47 Janine Bilsborough & Joanne L. Viney 5 Immunologic Memory: T Cells in Humans 61 Maria Candela Iglesias, Victor Appay, & Arnaud Moris 6 Immunologic Memory: B cells 79 F. Eun-Hyung Lee & Iñaki Sanz 7 Utility of Mouse Models in Vaccine Design and Development 94 Catharine M. Bosio, Megan MacLeod, Philippa Marrack, & Ross M. Kedl 8 Utility of Nonhuman Primate Models for Vaccines 110 Preston A. Marx, Jr & Alexander F. Voevodin Part 3 Antigen Discovery 9 Sequence-Based Computational Approaches to Vaccine Discovery and Design 133 Darrick Carter 10 Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies 150 D. Huw Davies 11 Phage Libraries 168 Aaron K. Sato Part 4 Antigen Engineering 12 Attenuated Bacterial Vaccines 181 Richard W. Titball & Helen S. Atkins 13 Virus-like Particles as Antigen Scaffolds 196 Bryce Chackerian & John T. Schiller 14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development 209 Yper Hall & Miles W. Carroll 15 Recombinant Adenoviruses for Vaccination 224 Nelson Cesar Di Paolo, Dmitry Shayakhmetov, & André Lieber 16 Recombinant Avipoxviruses 237 Michael A. Skinner & Stephen M. Laidlaw 17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy 255 Patrick Guirnalda, Laurence Wood, Matthew Seavey, & Yvonne Paterson 18 Nucleic Acid Vaccination 275 Britta Wahren & Margaret A. Liu 19 Artificial Antigen-presenting Cells: Large Multivalent Immu...

List of contents

List of Contributors, viii
 
Preface, xii
 
Part 1 Introduction
 
1 Concept and Scope of Modern Vaccines, 3
D. Huw Davies, Clint S. Schmidt, & Nadeem A. Sheikh
 
Part 2 Principles of Vaccine Design
 
2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants, 15
Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, & Volker Gerdts
 
3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules, 29
Antony N. Antoniou, Izabela Lenart, David B. Guiliano, & Simon J. Powis
 
4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design, 47
Janine Bilsborough & Joanne L. Viney
 
5 Immunologic Memory: T Cells in Humans, 61
Maria Candela Iglesias, Victor Appay, & Arnaud Moris
 
6 Immunologic Memory: B cells, 79
F. Eun-Hyung Lee & I ~ naki Sanz
 
7 Utility of Mouse Models in Vaccine Design and Development, 94
Catharine M. Bosio, Megan MacLeod, Philippa Marrack, & Ross M. Kedl
 
8 Utility of Nonhuman Primate Models for Vaccines, 110
Preston A. Marx, Jr & Alexander F. Voevodin
 
Part 3 Antigen Discovery
 
9 Sequence-Based Computational Approaches to Vaccine Discovery and Design, 133
Darrick Carter
 
10 Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies, 150
D. Huw Davies
 
11 Phage Libraries, 168
Aaron K. Sato
 
Part 4 Antigen Engineering
 
12 Attenuated Bacterial Vaccines, 181
Richard W. Titball & Helen S. Atkins
 
13 Virus-like Particles as Antigen Scaffolds, 196
Bryce Chackerian & John T. Schiller
 
14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development, 209
Yper Hall & Miles W. Carroll
 
15 Recombinant Adenoviruses for Vaccination, 224
Nelson Cesar Di Paolo, Dmitry Shayakhmetov, & Andr´e Lieber
 
16 Recombinant Avipoxviruses, 237
Michael A. Skinner & Stephen M. Laidlaw
 
17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy, 255
Patrick Guirnalda, Laurence Wood, Matthew Seavey, & Yvonne Paterson
 
18 Nucleic Acid Vaccination, 275
Britta Wahren & Margaret A. Liu
 
19 Artificial Antigen-presenting Cells: Large Multivalent Immunogens, 286
Matthew F. Mescher & Julie M. Curtsinger
 
Part 5 Delivery Systems
 
20 Transcutaneous Immunization via Vaccine Patch Delivery System, 303
Robert C. Seid, Jr & Gregory M. Glenn
 
21 Needle-free Jet Injection for Vaccine Administration, 324
Brian R. Sloat, Hoi K. Tran, & Zhengrong Cui
 
22 Oral Vaccines: An Old Need and Some New Possibilities, 336
Amit A. Lugade, Kalathil Suresh, & Yasmin Thanavala
 
23 Adjuvants: From Serendipity to Rational Discovery, 348
Derek T. O'Hagan & Andreas Wack
 
24 Immunostimulatory Properties of Biodegradable Microparticles, 361
Fiona A. Sharp & Ed C. Lavelle
 
25 Co-administration of Co-stimulatory Moieties, 375
Carolina Arancibia-C ´arcamo & Yvette Latchman
 
26 Toll Receptors in Relation to Adjuvant Effects, 393
Dipshikha Chakravortty, Amit Lahiri, & Priyanka Das
 
Part 6 Regulatory Considerations
 
27 Regulatory Issues (FDA and EMA), 403
Murrium Ahmad, Victoria Byers, & Peter Wilson
 
Part 7 Evaluating Vaccine Efficacy
 
28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine, 419
Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton, & Camilla Jandus
 
29 Clinical Development Strategy: Nuts and Bolts, 441
Candida Fratazzi & Claudio Carini
 
30 Current Approaches to Identify and Evaluate Can

Report

"Vaccinology provides an invaluable and authoritative resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines." ( Sir Read A lot , 10 May 2012)

Product details

• Authors: D. Huw Davies, John H. Schmidt Morrow, W. John W. Morrow, W. John W. (Seattle Morrow, W. John W. Sheikh Morrow, Ww Morrow, Clint S. Schmidt, Nadeem A. Sheikh
• Assisted by: Nadee A Sheikh (Editor), Nadeem A Sheikh (Editor), D. Huw Davies (Editor), Huw Davies (Editor), Davies D. Huw (Editor), John Morrow (Editor), W. John W. Morrow (Editor), Morrow W. John W. (Editor), Clint S Schmidt et al (Editor), Clint Schmidt (Editor), Clint S. Schmidt (Editor), Schmidt Clint S. (Editor), Nadeem A. Sheikh (Editor), Nazneen Sheikh (Editor), Sheikh Nadeem A. (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 10.08.2012
• EAN: 9781405185745
• ISBN: 978-1-4051-8574-5
• No. of pages: 560
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; Medizin, Infektionskrankheiten, Immunologie, Infektionskrankheit, infectious disease, Medical Science, Vakzinologie