Fr. 189.00

DNA Methylation: Development, Genetic Disease and Cancer

English · Paperback / Softback

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Description

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It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.

List of contents

The Regulation of Chromatin and DNA-Methylation Patterns in Blood Cell Development.- Methylation Dynamics in the Early Mammalian Embryo: Implications of Genome Reprogramming Defects for Development.- Epigenetic Regulation in Drosophila.- Epimutations in Human Disease.- Epigenotypes of Latent Herpesvirus Genomes.- Epigenetics of Complex Diseases: From General Theory to Laboratory Experiments.- MSL Proteins and the Regulation of Gene Expression.- DNA Methylation Profiles of Female Steroid Hormone-Driven Human Malignancies.- Genome-wide Analysis of DNA Methylation Changes in Human Malignancies.- Decreased Fidelity in Replicating DNA Methylation Patterns in Cancer Cells Leads to Dense Methylation of a CpG Island.- Methylation of Endogenous Human Retroelements in Health and Disease.- Cancer-Linked DNA Hypomethylation and Its Relationship to Hypermethylation.

Summary

It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.

Product details

Assisted by Böhm (Editor), Böhm (Editor), Petra Böhm (Editor), Walte Doerfler (Editor), Walter Doerfler (Editor)
Publisher Springer, Berlin
 
Languages English
Product format Paperback / Softback
Released 13.10.2010
 
EAN 9783642068300
ISBN 978-3-642-06830-0
No. of pages 284
Dimensions 150 mm x 20 mm x 224 mm
Weight 453 g
Illustrations IX, 284 p.
Series Current Topics in Microbiology and Immunology
Current Topics in Microbiology and Immunology
Subjects Natural sciences, medicine, IT, technology > Medicine > Clinical medicine

Protein, C, Virus, Gene, genetics, molecular biology, proteins, Human Genetics, Biomedical and Life Sciences, Medical Genetics, Developmental biology, Gene Therapy, Gene Expression, genes, genotypes

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