Progress in Medicinal Chemistry

Klappentext This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.

Product details

• Authors: Gwynn P. Ellis, King, F D King, F. D. King, F. D. Lawton King, F.D. King, F.d. (Smithkiine Beecham Pharmaceuticals New King, F.d. (Smithkiine Beecham Pharmaceuticals; King, G. Lawton, George Lawton, D. K. Luscombe, A. W. Oxford
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 15.04.2004
• EAN: 9780444511430
• ISBN: 978-0-444-51143-0
• No. of pages: 450
• Series: Progress in Medicinal Chemistr; Progress in Medicinal Chemistry; Progress in Medicinal Chemistry; Progress in Medicinal Chemistr
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; Pharmaceutical technology, Pharmaceutical chemistry and technology, TECHNOLOGY & ENGINEERING / Pharmaceutical