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Informationen zum Autor Dr. Andreas Inmann is a consultant and entrepreneur specializing in the development and commercialization of medical devices. Dr. Diana Hodgins is Managing Director of European Technology for Business, Ltd., a UK-based company that specializes in the design of microsystems and sensors. Klappentext Implantable sensor systems for medical applications can greatly improve quality of life and medical care. Consequently this field is receiving considerable interest and investment. This book discusses the core technologies needed for implantable sensor systems and their current and potential medical applications. Zusammenfassung This book discusses the core technologies needed for these sophisticated devices and their current and potential medical applications. Inhaltsverzeichnis Part 1 Fundamentals of implantable systems: Materials for implantable systems; Material-tissue interfaces in implantable systems; Packaging and coating materials for implantable systems; Microassembly and micropackaging of implantable systems; Electrode array design and fabrication for implantable systems; Biofuel cells as sustainable power sources for implantable systems. Part 2 Challenges of implantable systems: Biocompatibility of implantable systems; Sterilisation considerations for implantable sensor systems; Protection of data confidentiality and patient privacy in medical sensor networks; Developing active implantable medical devices in a regulated environment. Part 3 Applications of implantable systems: Microelectromechanical systems (MEMS) for in-vivo applications; Tripolar interfaces for neural recording; Sensors for motor neuroprostheses; Implantable wireless body area networks; Retina implants.
List of contents
Contributor contact details
Woodhead Publishing Series in Biomaterials
Foreword
Introduction
Part I: Fundamentals of implantable systems
Chapter 1: Materials for implantable systems
Abstract:
1.1 Introduction
1.2 Interactions between materials and the biological medium
1.3 Electrodes
1.4 Preferred electrode metals, compounds and polymers
1.5 Leads and interconnects
1.6 Packaging
1.7 Surface preparation
1.8 Conclusions
1.9 Future trends
1.10 Sources of further information
1.11 Acknowledgements
Chapter 2: Materialâ?"tissue interfaces in implantable systems
Abstract:
2.1 Introduction
2.2 Fundamental requirements of material-tissue interfaces
2.3 Material selection for implantable systems
2.4 Design considerations and packaging concepts
2.5 Approaches to reduce reactions at the material-tissue interface
2.6 Conclusions
2.7 Future trends
2.8 Sources of further information
Chapter 3: Packaging and coating materials for implantable devices
Abstract:
3.1 Introduction
3.1.1 Background
76 Implantable sensor systems for medical applications 3.1.3 Current packaging and coating strategies
3.2 Packaging of the passive device surface
80 Implantable sensor systems for medical applications 3.2.2 Silicone
3.3 Coating of active device surfaces
3.4 Coatings and barriers for drug release
3.5 Enhancement of surface biocompatibility
3.6 Conclusions
3.7 Future trends
Chapter 4: Microassembly and micropackaging of implantable systems
Abstract:
4.1 Introduction
4.2 Components of an implanted sensor system
4.3 Microassembly
4.4 Micropackaging
4.5 Conclusions
4.6 Future trends
4.7 Sources of further information
Chapter 5: Electrode array design and fabrication for implantable systems
Abstract:
5.1 Introduction
5.2 General requirements for implantable electrode arrays
5.3 Materials for implantable electrodes
5.4 The processing of silicone as a substrate material
5.5 Coating layers for microelectrodes
5.6 Fabrication of electrodes using platinum
5.7 Microelectrode arrays - design and fabrication
5.8 Advantages and disadvantages of existing fabrication processes
5.9 Risks
5.10 Conclusions
5.11 Future trends
5.12 Sources of further information
Chapter 6: Biofuel cells as sustainable power sources for implantable systems
Abstract:
6.1 Introduction
6.2 Implantable biofuel cells
6.3 Design considerations
6.4 State-of-the-art and practical examples
6.5 Conclusions and future trends
6.6 Sources of further information
Part II: Challenges of implantable systems
Chapter 7: Biocompatibility of implantable systems
Abstract:
7.1 Introduction
7.2 The nature of the biological milieu
7.3 The course of events following insertion of an implantable system
7.4 Interfacial interactions
7.5 Biological and chemical processes which can affect implantable systems
7.6 Modelling protein adsorption
7.7 The immune response
7.8 Hydrodynamic aspects of biocompatibility
7.9 Tribological aspects of biocompatibility
7.10 Corrosion
7.11 Cell-implant interactions
7.12 The metrology and evaluation of biocompatibility
7.13 Conclusions
7.14 Future trends
7.15 Sources of further information
Chapter 8: Sterilisation considerations for implantable sensor systems
Abstract:
8.1 Introduction
8.2 Global markets and the regulatory context
8.3 Methods for sterilisation of medical devices
8.4 Sterilisation of implantable sensor systems
8.5 Conclusio
Report
"The book really illustrates the complexity when it comes to biosensor development and implantation, which will encourage a lot of researchers to broaden their perspective beyond their own research area." --Drs. Elke Van De Walle, Ghent University, Belgium. Biomaterials Network
