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This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician. With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.
List of contents
X-ray analysis of prokaryotic and eukaryotic ribosomes.- A passage through the ribosome by Cryo-EM.- Molecular dynamics simulations of the ribosome.- Structural analyses of the ribosome by chemical modification methods.- Methods for studying the interactions of translation factors with the ribosome.- Riboproteomic approaches to understanding IRES elements.- Rapid kinetic analysis of protein synthesis.- Investigating RNAs Involved in Translational Control by NMR and SAXS.- Analyses of RNA-ligand interactions by fluorescence anisotropy.- Approaches for the Identification and Characterization of RNA-Protein Interactions.- A multidisciplinary approach to RNA Localization.- Virtual Screening for RNA-interacting Small Molecules.- The 'fifth' RNA nucleotide: a role for ribosomal RNA pseudouridylation in control of gene expression at the translational level.- Translational Control of Synaptic Plasticity and Memory.
Summary
This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician. With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.
