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This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors' own laboratories.
List of contents
This book consists of 29 chapters and is divided into the following four Parts: Part I Molecular biology of Selected Hemato-oncologic Diseases.- Part II Diagnostics and Monitoring of Therapy of Hemato-oncologic Diseases.- Part III Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation.- Part IV Molecular Diagnostic Protocols.
Summary
This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.
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From the reviews:
“This book describes current diagnostic tools and clinical procedures used for hematological malignancies. … The goal was to meet the needs of both clinical hematologists who treat patients with leukemia, lymphoma, and/or multiple myeloma and those who study these diseases in the laboratory. … an excellent review of molecular biology for specific hematological malignancies and disorders. It also covers important molecular testing techniques that are commonly used in the diagnosis, management, and surveillance of these malignancies. … a valuable addition to any hematologist’s library.” (John Patrick Galvin, Doody’s Review Service, October, 2012)
Report
From the reviews:
"This book describes current diagnostic tools and clinical procedures used for hematological malignancies. ... The goal was to meet the needs of both clinical hematologists who treat patients with leukemia, lymphoma, and/or multiple myeloma and those who study these diseases in the laboratory. ... an excellent review of molecular biology for specific hematological malignancies and disorders. It also covers important molecular testing techniques that are commonly used in the diagnosis, management, and surveillance of these malignancies. ... a valuable addition to any hematologist's library." (John Patrick Galvin, Doody's Review Service, October, 2012)
