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Sepsis represents a life threatening condition to ICU patients. The evolution of sepsis to severe sepsis or septic shock may occur in an unpredictable way. In the coming millennium the prevention and management of sepsis and organ dysfunction will present a real challenge for researchers and clinicians.
List of contents
Basic Pathophysiology Mechanics.- Inflammation: How Much Is Too Much and Can It Be Controlled.- Injury, Inflammation, Sepsis - Is There a Natural, Organized and Sequential Progression of Neuroendocrine, Metabolic and Cytokine Mediator Events Leading to Organ System Failure.- Genetic Predisposition to Sepsis and Organ Failure.- Regulation of the Lung Inflammatory Response.- Clinical Interventions in the Field of Sepsis What is Wrong and What is Right.- Shall We Continue to Talk About (or Use) SIRS in the Twenty-first Century.- Prevention and Treatment of Sepsis - Present and Future Problems.- Sepsis and MODS - What Is Wrong and What Is Right.- What Is Clinical Relevance? - Well Controlled Experiments in Normal Animals as Compared to Clinical Studies in Diverse Sick Patients.- The Markers of Sepsis.- Apoptosis (Programmed Cell Death) and the Resolution of Acute Inflammation.- "Untimely Apoptosis" Is the Password.- Multiple Therapeutic Agents - Will Individual Therapies, Each of Which Improves Patients, When Given Together, Change Mortality.- Endotoxaemia in Critical Illness: Rapid Detection and Clinical Relevance.- New and Old Markers in Sepsis.- From Cytokines through Immune Effector Cells to the Body.- Intravenous Immunoglobulins: Are They Helpful.- Clinical Aspects of Splanchnic Ischaemia and Oxygen Metabolism.- Is Splanchnic Perfusion a Critical Problem in Sepsis.- Metabolism and O2 Consumption in Trauma and Sepsis.- Intragastric pH (ipH) and PaCO2 Monitoring in Sepsis.
