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Cardiac performance is regulated not only by cardiac muscle properties but also by several other factors, including those associated with the neurohumoral system and the mechanical characteristics of the peripheral circulation. New information con cerning these regulatory factors has furthered our understanding of the pathophysi ology of cardiac dysfunction. However, controversy remains, along with a need to integrate these multidisciplinary findings. It was with this in mind, together with my continuing interest in the response of the normal and diseased heart to variations in loading conditions, that the satellite symposium entitled "Interactions Between Car diac Function and Vascular Dynamics" was organized and dedicated to my mentor, Dr. T. Takishima. The symposium was held in Fukushima, Japan, in 1992 following the Tenth Inter national Conference of the Cardiovascular Systems Dynamics Society in Kobe, Japan, which was organized by the then president of the society, Dr. Masatsugu Hori. The Fukushima symposium and the Kobe conference were stimulating and informative. To commemorate these events, Dr. Hori, Dr. Janicki, and I decided to publish this book. It covers topics that were presented then as well as pertinent new material. As a result, the book includes not only updated reviews but also up-to-date findings that were not considered at the two scientific sessions. The high level attained in this book is due to the outstanding contributions from internationally renowned scientists. This final product of their efforts should prove to be a valuable source of information to the reader.
List of contents
1 Ventricular-Vascular Adaptation and Remodeling Vascular Remodeling.- During Heart Failure.- Myocardial Interstitial Collagen Matrix Remodeling in Response to a Chronic Elevation in Ventricular Preload or Afterload.- Myocardial Hypertrophy and Coronary Circulation Before and After Relief of Pressure Overload.- Cardiac Hypertrophy and the Renin-Angiotensin System.- The Role of Manganese Superoxide Dismutase in the Acquisition of Tolerance of the Heart to Ischemia: Molecular Adaptation to Ischemia.- Remodeling: How Vessels Narrow.- 2 Systolic-Diastolic Interaction.- Interaction Between Left-Ventricular Function and Loading Condition in Cardiovascular Disease.- Intraventricular Interaction.- Adaptation of the Cardiac Cell to Loading: Function in Heart Failure.- Transient Hemodynamic Perturbations: An Approach to the Study of Ventricular Interaction and Restoring Forces.- Extrinsic Versus Intrinsic Determinants of the Diastolic Pressure-Volume Relation.- Endocardial-Myocardial Interaction.- 3 Ventricular-Vascular Interaction.- Arterial Compliance as Load on the Heart.- Optimal Afterload that Maximizes External Work and Optimal Heart that Minimizes O2 Consumption.- Influence of Aortic Impedance on the Development of Pressure-Overloaded Left-Ventricular Hypertrophy in Rats.- The Arterial Response to an Exercise Stress Test in Healthy Subjects, Hypertensives, and Patients with Left-Ventricular Dysfunction.- Altered Left-Ventriculoarterial Coupling in Mitral Regurgitation.- Aging Changes in the Systemic Circulation and Ventriculovascular Coupling.- The Veins and Ventricular Preload.- Role of Endothelium in Control of Regional Blood Flow in Humans.- Dynamic Characteristics of the Pulmonary Circulation.- Intramyocardial Regulation of Coronary Dynamics.- Coronary SloshPhenomenon and Behavior of Intramyocardial Microcirculation.- Coronary-Ventricular Interaction: The Gregg Phenomenon.- Influences of Coronary Venous Pressures on Left-Ventricular Function.- Coronary Pressure-Flow Relations.- Nitric Oxide and the Heart: Implications in Physiological and Pathological Conditions.- Cardiac Mechanoenergetics and Coronary Circulation.
