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Since the discovery of superoxide dismutase more than three decades ago, there has been rapid growth in the knowledge of oxidative stress and disease. This volume containing the proceedings of the 13th Yamaguchi Symposium on Liver Disease includes discussion of the direct cellular effects of hepatitis C virus (HCV) proteins on hepatocytes and reviews evidence that oxidative stress caused primarily by the HCV core protein plays a key role in disease pathogenesis. Also included are chapters on new aspects of oxidative stress and liver disease such as carbon monoxide as a regulator of liver microcirculation, hepatic iron accumulation and the incidence of hepatocellular carcinoma, and oxidative stress in the absence of inflammation in hepatocarcinogenesis. This collection of papers from the Yamaguchi Symposium creates a valuable reference resource for physicians and hepatologists.
List of contents
Alcohol-HCV Interactions in Transgenic Mice Expressing Viral Proteins in the Liver.- Role of Core Protein-Induced Oxidative Stress in the Pathogenesis of Hepatitis C.- Hepatitis C Virus Core-Mediated Alteration of Gene Expression and Signal Transduction in the Host Cell.- Signals Induced by HCV Proteins.- Role of Hepatitis C Virus in Hepatocarcinogenesis: Oxidative Stress in the Absence of Inflammation.- Reduced Chemical Hepatocarcinogenesis in Interferon-? Receptor Knockout Mice.- Fewer Somatic Mutations of Mitochondrial DNA in Noncancerous Liver Tissue Patients with Hepatocellular Carcinoma Respond to Interferon Therapy.- Hepatic Iron Staining in Chronic Hepatitis C Patients with Low HCV RNA Levels as a Predictive Marker for Interferon Therapy.- Hepatic Iron Accumulation and Incidence of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C.- Carbon Monoxide as a Gaseous Regulator of Liver Microcirculation.- Tamoxifen-Induced Nonalcoholic Steatohepatitis.
Summary
Since the discovery of superoxide dismutase more than three decades ago, there has been rapid growth in the knowledge of oxidative stress and disease. This volume containing the proceedings of the 13th Yamaguchi Symposium on Liver Disease includes discussion of the direct cellular effects of hepatitis C virus (HCV) proteins on hepatocytes and reviews evidence that oxidative stress caused primarily by the HCV core protein plays a key role in disease pathogenesis. Also included are chapters on new aspects of oxidative stress and liver disease such as carbon monoxide as a regulator of liver microcirculation, hepatic iron accumulation and the incidence of hepatocellular carcinoma, and oxidative stress in the absence of inflammation in hepatocarcinogenesis. This collection of papers from the Yamaguchi Symposium creates a valuable reference resource for physicians and hepatologists.
