Organic Chemistry - Breakthroughs and Perspectives

Dieses Lehrbuch präsentiert die bedeutendsten Entwicklungen des letzten Jahrzehnts in der organischen Chemie und bietet zu jedem Kapitel und Thema bislang unveröffentlichte, persönliche Einschätzungen namhafter Experten.

List of contents

INTRODUCTIONDIVERSITY-ORIENTED SYNTHESES OF NATURAL PRODUCTS AND NATURAL PRODUCT-LIKE COMPOUNDSIntroductionDiversity-Oriented Synthesis (DOS)Diverted Total Synthesis (DTS) Function-Oriented Synthesis (FOS)Target-Oriented Synthesis (TOS) Conclusion and PerspectivesTOTAL SYNTHESIS OF NATURAL PRODUCTS AND THE SYNERGY WITH SYNTHETIC METHODOLOGY Introduction Domino ProcessMulticomponent Reactions Oxidative Anion Coupling Pattern Recognition Conformation-Directed Cyclization Conclusion and Perspectives INTERPLAY BETWEEN THE CHEMICAL SPACE AND THE BIOLOGICAL SPACE Chemical Biology: Historical and Philosophical Aspects Preparation of Chemical Libraries Screening Strategies Target Elucidation and Validation Conclusion and Perspectives BIOSYNTHESIS OF PHARMACEUTICAL NATURAL PRODUCTS AND THEIR PATHWAY ENGINEERING Introduction Expanded Paradigms in Biosynthetic Logic New Approaches to NP Biosynthesis Research Better Understanding of the Scope and Diversity of NP Production Future PerspectivesCARBOHYDRATE SYNTHESIS TOWARDS GLYCOBIOLOGY Introduction Advances in Chemical Glycosylation New Strategies in Oligosaccharide Assembly Enzymatic and Chemoenzymatic Methods Synthesis of Heparin and Heparan Sulfate Oligosaccharides Synthesis of Homogeneous Glycoproteins Synthesis of Carbohydrate-Containing Complex Natural CompoundsConclusion and Perspectives CHEMICAL SYNTHESIS OF PROTEINS IntroductionBrief History Current Technology Applications Conclusion and Perspectives CUAAC: THE QUINTESSENTIAL CLICK REACTION Introduction Azide - Alkyne Cycloaddition: the Basics CuAAC: Catalysts and Ligands Mechanistic Aspects of the CuAAC Reactions of 1-IodoalkynesExamples of Application of the CuAAC Reaction Reactions of Sulfonyl Azides Outlook/Perspective TRANSITION METAL-CATALYZED C - H FUNCTIONALIZATION: SYNTHETICALLY ENABLING REACTIONS FOR BUILDING MOLECULAR COMPLEXITY Introduction Background and Early Work First Functionalization: Challenges in Hydrocarbon Chemistry Further Functionalization: C - H Bonds as Reaction Partners in Organic Synthesis Catalytic C - H Functionalization via Metal Insertion Other Emerging Metal-Catalyzed Further Functionalization Methods Outlook and Conclusion AN OVERVIEW OF RECENT DEVELOPMENTS IN METAL-CATALYZED ASYMMETRIC TRANSFORMATIONS Introduction Asymmetric Carbon - Carbon Bond Formation Asymmetric Reductions and Oxidations Conclusion THE PROLINE-CATALYZED MANNICH REACTION AND THE ADVENT OF ENAMINE CATALYSIS Introduction The Proline-Catalyzed Mannich ReactionConclusion RECENT TOPICS IN COOPERATIVE CATALYSIS: ASYMMETRIC CATALYSIS, POLYMERIZATION, HYDROGEN ACTIVATION, AND WATER SPLITTINGIntroduction Cooperative Catalysis in Asymmetric ReactionsCooperative Catalysis in Alkene Polymerization Cooperative Catalysis in Hydrogen Activation/Generation Conclusion and Perspectives FLOURISHING FRONTIERS IN ORGANOFLUORINE CHEMISTRY Introduction Synthetic Approaches for the Introduction of Fluorine-Containing Functionalities and Related Chemistry Conclusion and Perspectives SUPRAMOLECULAR ORGANIC CHEMISTRY: THE FOLDAMER APPROACH Introduction Foldamers: the BackgroundMolecular Recognition Homoduplex Organogels Vesicles Supramolecular Liquid Crystals MacrocyclesCatalysis Macromolecular Self-AssemblyConclusion and Perspectives NOVEL CATALYSIS FOR ALKENE POLYMERIZATION MEDIATED BY POST-METALLOCENES: A GATEWAY TO NEW POLYALKENES IntroductionLate Transition Metal Complexes Early Transition Metal Complexes Conclusion and Perspectives CHEMISTRY COMPUTATIONALLY AND EXPERIMENTALLY: HOW WILL COMPUTATIONAL ORGANIC CHEMISTRY IMPACT ORGANIC THEORIES, MECHANISMS, AND SYNTHESIS IN THE TWENTY-FIRST CENTURY?Introduction Developing New Theories, Concepts, and Understandings for Organic Chemistry Understanding Reaction MechanismsComputation-Guided Development of New Catalysts, New Reactions, and Synthesis Planning for Ideal Synthesis Conclusion CASE STUDY OF MECHANISMS IN SYNTHETIC REACTIONS Introduction Mechanistic Study of Coupling ReactionsMechanistic Study of Aerobic Oxidation Conclusion and Perspective ORGANIC MATERIALS AND CHEMISTRY FOR BULK HETEROJUNCTION SOLAR CELLS Introduction Molecular Design and Engineering of Donor Materials Molecular Design and Engineering of Acceptor Materials Conclusion and Outlook CATALYTIC UTILIZATION OF CARBON DIOXIDE: ACTUAL STATUS AND PERSPECTIVES IntroductionCatalytic Reductions of CO2 to Formic Acid and MethanolCO2 as a C1-Building Block in C - C Coupling ReactionsCatalytic C - O Bond Formation Utilizing Carbon Dioxide Current Industrial Processes Using CO2 Conclusion and Outlook SYNTHETIC CHEMISTRY WITH AN EYE ON FUTURE SUSTAINABILITY Introduction Cross-Dehydrogenative Coupling Nucleophilic Addition of Terminal Alkynes in Water Conclusion and PerspectivesORGANIC Pi-CONJUGATED MOLECULES FOR ORGANIC SEMICONDUCTORS AND PHOTOVOLTAIC MATERIALS Introduction Conjugated Molecules for p-Type Organic Semiconductors Conjugated Molecules for n-Type Organic Semiconductors Conjugated Molecules for Photovoltaic Materials Conclusion and Outlook THE FUTURE OF ORGANIC CHEMISTRY - AN ESSAY Introduction The Field of Organic Chemistry Will Broaden Conclusion

About the author

Li-Xin Dai is professor at the famous Shanghai Institute of Organic Chemistry. He has authored or co-authored over 150 scientific publications and has received numerous scientific awards, including Ho Leung Ho Lee Prize and the National Natural Science Award of China. His research interests include new synthetic methodology, asymmetric synthesis, and design of novel chiral ligands. He is also a member of Chinese Academy of Sciences, an expert analyst in organic chemistry of Chemtracts and a member of advisory board of Chemical Society Reviews.

Summary

Dieses Lehrbuch präsentiert die bedeutendsten Entwicklungen des letzten Jahrzehnts in der organischen Chemie und bietet zu jedem Kapitel und Thema bislang unveröffentlichte, persönliche Einschätzungen namhafter Experten.

Report

"This volume, though oriented primarily to major developments in synthesis and chemical biology, with relatively little attention to topics in physical organic chemistry such as nonclassical carbocations, is a valuable resource for all academic and professional chemistry collections. Summing Up : Highly recommended. Lower-division undergraduates and above." ( Choice, 1 July 2013)

Product details

• Authors: Li-Xin Dai, Kuiling Ding
• Assisted by: Dai (Editor), Dai (Editor), Li-Xin Dai (Editor), Kuilin Ding (Editor), Kuiling Ding (Editor)
• Publisher: Wiley-VCH
• Languages: English, German
• Product format: Paperback / Softback
• Released: 01.08.2012
• EAN: 9783527329632
• ISBN: 978-3-527-32963-2
• No. of pages: 802
• Dimensions: 170 mm x 240 mm x 44 mm
• Weight: 1786 g
• Illustrations: 550 SW-Abb., 42 Farbabb., 12 Tabellen
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Chemie, Organische Chemie, Katalyse, chemistry, Catalysis, Methods - Synthesis & Techniques, Organische Chemie / Methoden, Synthesen, Verfahren, Biochemie u. Chemische Biologie, Biochemistry (Chemical Biology)