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Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.
List of contents
Beta-Cell Expansion and Regeneration.- Pancreas and Islet Development.- Islet and Pancreas Transplantation.- Cell Cycle Regulation in Human Pancreatic Beta Cells.- Islet Regeneration.- Beta-Cell Expansion in Vitro.- Beta Cells from Non-beta Cells.- What Does It Take to Make a Beta Cell?.- Generation of Beta Cells from Acinar Cells.- Generation of Beta Cells from Pancreatic Duct Cells and/or Stem Cells.- Adult Cell Reprogramming: Using Nonpancreatic Cell Sources to Generate Surrogate Beta Cells for Treatment of Diabetes.- Embryonic Stem Cells as a Potential Cure for Diabetes.- Tissue Engineering and Immune Protection.- Functional Tissue Reconstruction with the Use of Biologic Scaffolds.- Immunoisolation in Cell Transplantation.- Prevention of Islet Graft Rejection and Recipient Tolerization.
Summary
Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming.
Additional text
From the reviews:
“From the same Series as the previous book, this volume reviews in 3 parts new methods in replacing beta cells to man. … For research diabetologists.” (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)
“This book details the promising role of stem cells to generate insulin-producing cells for replacement of diseased cells in diabetes therapy. … All recent research findings are discussed, providing a well-rounded view of the current approaches to generating new insulin-producing cells. This book is informative, well illustrated with figures … . I would suggest this book for scientists or clinicians who want to learn and understand new approaches to generate and restore beta cells as a promising approach to curing diabetes.” (Damien Demozay, Doody’s Review Service, July, 2010)
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From the reviews:
"From the same Series as the previous book, this volume reviews in 3 parts new methods in replacing beta cells to man. ... For research diabetologists." (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)
"This book details the promising role of stem cells to generate insulin-producing cells for replacement of diseased cells in diabetes therapy. ... All recent research findings are discussed, providing a well-rounded view of the current approaches to generating new insulin-producing cells. This book is informative, well illustrated with figures ... . I would suggest this book for scientists or clinicians who want to learn and understand new approaches to generate and restore beta cells as a promising approach to curing diabetes." (Damien Demozay, Doody's Review Service, July, 2010)
