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Informationen zum Autor JIE JACK LI, PhD, is a chemist at Bristol-Myers Squibb Company. He has authored or edited several books published by Wiley, including Name Reactions in Heterocyclic Chemistry, Name Reactions for Functional Group Transformations, Name Reactions for Homologations (Part I and Part II), Name Reactions for Carbocyclic Ring Formations, Contemporary Drug Synthesis, The Art of Drug Synthesis, and Modern Drug Synthesis. E. J. COREY, PhD, has been a Professor at Harvard University since 1959. The 1990 Nobel Laureate in Chemistry, Dr. Corey has also been the recipient of more than seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal. Author of more than 1,500 publications, he is one of the most cited authors in science. Klappentext Sets forth the history, state of the science, and future directions of drug discoveryEdited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design.Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as:* Target identification and validation* Drug metabolism and pharmacokinetics* Central nervous system drugs* In vitro and in vivo assays* Cardiovascular drugs* Cancer drugsEach chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field.Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery. Zusammenfassung Edited by two distinguished chemists from academia and industry, this book presents an up-to-date overview of major aspects of drug discovery. It covers all ends of the discovery process from target selection to major therapeutic areas. Inhaltsverzeichnis Chapter 1. History of Drug Discovery 1 1. Introduction 1 2. Antibacterials 1 3. Cancer Drugs 6 4. Cardiovascular Drugs 10 5. Cholesterol Drugs 16 6. CNS Drugs 21 7. Anti-inflammatory Drugs 26 8. Anti-ulcer Drugs 30 9. Antiviral Drugs 33 10. References 38 Chapter 2. Target Identification and Validation 43 1. History 43 2. Definition of Drug Targets 43 3. Classification of Currently Utilized Drug Targets 45 4. Receptors as Drug Targets 46 5. Enzymes as Drug Targets 48 6. Transporter Proteins as Drug Targets 49 7. Modern Technologies Employed in Target Identification and Validation 49 8. Impact of Therapeutic Modalities on the Selection Drug Targets 62 9. Future Directions 63 10. References 3. In vitro and in vivo Assays 67 1. Introduction 67 2. The Testing Funnel 67 3. In vitro assays 70 4. In vivo Assays 89 5. Outlook 92 6. References 93 Chapter 4. Drug Metabolis...
