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Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful Neuromethods(TM) series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field.
Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.
List of contents
The Open Field Test.- Analysis of Grooming Behavior and Its Utility in Studying Animal Stress, Anxiety, and Depression.- Digging in Mice: Marble Burying, Burrowing, and Direct Observation Reveal Changes in Mouse Behavior.- Circadian and Light Modulation of Behavior.- Ultrasonic Vocalizations by Infant Mice: An Ethological Expression of Separation Anxiety.- The Forced Swimming Test in Mice: A Suitable Model to Study Antidepressants.- The Tail-Suspension Test: A Model for Characterizing Antidepressant Activity in Mice.- Stress-Induced Hyperthermia in the Mouse.- Factors of Reproducibility of Anhedonia Induction in a Chronic Stress Depression Model in Mice.- Learned Helplessness in Mice.- The Mouse Light-Dark Box Test.- Using the Elevated Plus Maze as a Bioassay to Assess the Effects of Naturally Occurring and Exogenously Administered Compounds to Influence Anxiety-Related Behaviors of Mice.- Novelty-Induced Hypophagia.- Acute and Chronic Social Defeat: Stress Protocols and Behavioral Testing.- Reduction of Submissive Behavior Model for Antidepressant Drug Testing in Mice.- Mice Models for the Manic Pole of Bipolar Disorder.
Summary
World-renowned researchers outline behavioral approaches used in characterizing mood and anxiety-related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds.
Additional text
From the reviews:
“Part of the Neuromethods Series, this book describes behavioral protocols that are used in laboratory experiments with mice in order to understand mood and anxiety related phenotypes. … This excellent book describes specific behavioral tests in great detail. Readers who have a strong foundation in research will be very pleased because they can replicate the tests with the information here and the protocols are analyzed in terms of their usefulness.” (Gary B. Kaniuk, Doody’s Review Service, June, 2010)
Report
From the reviews:
"Part of the Neuromethods Series, this book describes behavioral protocols that are used in laboratory experiments with mice in order to understand mood and anxiety related phenotypes. ... This excellent book describes specific behavioral tests in great detail. Readers who have a strong foundation in research will be very pleased because they can replicate the tests with the information here and the protocols are analyzed in terms of their usefulness." (Gary B. Kaniuk, Doody's Review Service, June, 2010)
