Plant Bioactives and Drug Discovery - Principles, Practice, and Perspectives

Informationen zum Autor Valdir Cechinel-Filho, PhD , is Professor and Researcher at the Chemical-Pharmaceutical Investigations Center, University of Vale do Itajaí in Brazil. The editor of five books, seventeen contributed chapters, and over 250 scientific papers and reviews, Dr. Filho is also Associate Editor of Pharmaceutical Biology , a member of the editorial boards of several journals, and a reviewer for many journals, including European Journal of Medicinal Chemistry , Journal of Pharmacy and Pharmacology , Natural Product Research , Planta Medica , and Journal of Agricultural and Food Chemistry . Klappentext An in-depth exploration of the applications of plant bioactive metabolites in drug research and developmentHighlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today.With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications.Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields. Zusammenfassung An in-depth exploration of the applications of plant bioactive metabolites in drug research and developmentHighlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today.With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications.Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields. Inhaltsverzeichnis Contributors xv Preface xix 1 Natural Products in Drug Discovery: ...

List of contents

Contributors xv
 
Preface xix
 
1 Natural Products in Drug Discovery: Recent Advances 1
Gordon M. Cragg, Paul G. Grothaus, and David J. Newman
 
1.1 Introduction 1
 
1.2 The Role of Traditional Medicine and Plants in Drug Discovery 2
 
1.3 The Role of Marine Organisms in Drug Discovery 4
 
1.4 The Role of Microorganisms in Drug Discovery: An Historical Perspective 6
 
1.5 Other Sources 8
 

1.6 The Importance of Natural Products in Drug Discovery and Development 8
 
1.7 Classical Natural Sources: Untapped Potential 10
 
1.8 The Unexplored Potential of Microbial Diversity 10 1.9 Development of Drugs From Natural Products: A Multidisciplinary Process 19
 
1.10 Conclusions 26
 
References 27
 
2 Modern Approaches in the Search for New Active Compounds from Crude Extracts of Natural Sources 43
Emerson F. Queiroz, Kurt Hostettmann, and Jean-Luc Wolfender
 
2.1 Introduction 43
 
2.2 Selection of the Natural Matrices 45
 
2.3 Rapid Online Identification and Dereplication 46
 
2.4 HPLC-Hyphenated Methods for Natural Product Identification 46 2.5 Studies on Natural Products Using LC-NMR, Microflow NMR, and SPE-NMR 57
 
2.6 Application of Direct NMR Methods for Chemical Profiling of Crude Extracts 67 2.7 Conclusions 69
 
References 71
 
3 Natural Products as Lead Compounds in Medicinal Chemistry 81
Eliezer J. Barreiro, Carlos A. M. Fraga, and Lidia M. Lima
 
3.1 Medicinal Chemistry Definition and the Importance of the Lead Compound in Drug Discovery 81
 
3.2 Natural Products as Drugs 84 3.4 Natural Products as Lead Compounds for New Drug Candidates 107
 
3.5 Conclusions 113
 
Acknowledgments 115
 
References 115
 
4 The Importance of Structural Manipulation of Natural Compounds in Drug Discovery and Development 127
Arturo San Feliciano, María Á . Castro, José L. López-Perez, and Esther del Olmo
 
4.1 Introduction 127
 
4.2 Chemomodulation of Podophyllotoxin Cyclolignans 132 4.3 Chemoinduction of Bioactivity on Dihydrostilbenoids 140
 
4.4 Chemoinduction and Chemomodulation of the Antiparasitic Activity of Stilbenoids 150
 
4.5 Conclusions 152
 
Acknowledgments 153
 
References 153
 
5 The Action of Plants and their Constituents on the Central Nervous System 161
Fúlvio R. Mendes, Giuseppina Negri, Joaquim M. Duarte-Almeida, Ricardo Tabach, and Elisaldo A. Carlini
 
5.1 Introduction 161
 
5.2 Plants with CNS Depressant Activity 162 5.3 Plants with the CNS Stimulant Activity 169
 
5.4 Plants Used as Antidepressants 174 5.5 Adaptogenic Plants 175
 
5.6 Plants Used to Treat Neurodegenerative Diseases 178 5.7 Plants with the Mind-Altering Activity 182
 
5.8 Plants Used Against Drug Dependence 188
 
5.9 Conclusions 188
 
Acknowledgments 191
 
References 191
 
6 The Role of Natural Products in Discovery of New Anti-Infective Agents with Emphasis on Antifungal Compounds 205
Maximiliano Sortino, Marcos Derita, Laura Svetaz, Marcela Raimondi, Melina Di Liberto, Elisa Petenatti, Mahabir Gupta, and Susana Zacchino
 
6.1 Infectious Diseases and Available Antimicrobial Agents 205
 
6.2 Fungal Infections and Available Antifungal Agents 206 6.3 The Need of New Antifungal Agents 208
 
6.4 From Antifungal Compounds to Antifungal Drugs: Some Considerations 223
 
6.5 Other Strategies Based on Non-targeted Assays 223
 
6.6 Strategies Based on Targeted Assays for the Discovery of Antifungal Compounds 226 6.7 Conclusion 229
 
References 229
 
7 Antiulcer Agents from Higher Plants 241
Luiz C. Klein-Júnior, Jo

Report

"In conclusion, this book could be a useful guide not only for PhD students starting their activity in the field of plant metabolites, but also for more advanced researchers looking for a state-of-the-art overview of modern research in this fascinating field." ( ChemMedChem , 1 March 2013)

Product details

• Authors: CECHINEL FILHO VALDIR, Valdir Cechinel-Filho, Cechinel-Filho Valdir, V Filho, Valdir Filho, Valdir Cechinel Filho
• Assisted by: Valdir Cechinel-Filho (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 08.06.2012
• EAN: 9780470582268
• ISBN: 978-0-470-58226-8
• No. of pages: 592
• Series: Wiley series in drug discovery and development; Wiley Series in Drug Discovery; Wiley series in drug discovery and development; Wiley Drug Discovery and Devel
• Subjects: Guides > Health; Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Chemie, Life Sciences, Wirkstoffforschung, Biowissenschaften, chemistry, Natural Products, Naturstoffchemie, Plant Biochemistry, Wirkstoffforschung u. -entwicklung, Drug Discovery & Development, Botanik / Biochemie