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A First Course in Systems Biology is intended as a first introduction of advanced undergraduate or graduate students to the new paradigm of systems biology. Its main focus is on the development of computational models and their applications to diverse biological systems. This book provides the reader with sufficient background and access to methods to execute standard systems biology tasks, understand the modern literature and launch into specialized courses or projects that address biological questions with theoretical and computational means. The format of the book is a combination of instructional text, reference to the literature, and hands-on experience, which is complemented with sets of probing questions, small-scope exercises, and larger-scale, often open-ended questions.
List of contents
1. Biological Systems 2. Introduction to Mathematical Modeling 3. Static Network Models 4. The Mathematics of Biological Systems 5. Parameter Estimation 6. Gene Systems 7. Protein Systems 8. Metabolic Systems 9. Signaling Systems 10. Population Systems 11. Integrative Analysis of Genome, Protein, and Metabolite Data 12. Physiological Modeling: the Heart as Example 13. Systems Biology in Medicine and Drug Development 14. Design of Biological Systems 15. Emerging Topics in Systems Biology
