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Despite recent advances, the pathogenesis and therapy of various forms of chronic inflammatory diseases of the gastrointestinal tract remains problematical. Especially threatening is the possible complication of the development of a malignant growth, but the role of the chronic inflammatory process in this is not known. Three examples are: H. pylori-induced gastritis is associated with gastric lymphomas and carcinomas; there is an increased incidence of intestinal T-cell lymphomas in tropical sprue; and chronic inflammatory bowel diseases, particularly ulcerative colitis, are associated with an increased incidence of carcinoma.
In this book, the Proceedings of Falk Symposium No. 81, held in Berlin, November 3-5, 1994, an extensive exchange of information and opinions between international experts yields a state-of-the-art consensus on practical procedures in diagnostics, prophylaxis and therapy.
List of contents
List of principal authors. Introduction. Section I: Helicobacter pylori and malignant transformation. Helicobacter pylori infection - clinical aspects and epidemiology; M. Gregor. Helicobacter pylori: mechanisms of pathogenicity; J.-D. Schulzke, et al. Significance of Helicobacter pylori infection for malignant transformation of epithelial cells; M. Stoltes, S. Eidt. Cytokine responses to Helicobacter pylori infection; J.E. Crabtree. The role of Helicobacter pylori in the pathogenesis of primary gastric B-cell lymphoma; P.G. Isaacson. In vitro studies of malignant B cells from low grade B cell gastric lymphoma of mucosa associated lymphoid tissue; T. Hussell, et al. Section II: Coeliac disease and enteropathy-associated lymphomas. Clinical and pathological spectrum of coeliac disease; A. Ferguson, et al. Genetic susceptibility to coeliac disease; M.F. Kagnoff. Phenotype and functions of intraepithelial lymphocytes; N. Cerf-Bensussan, D. Guy-Grand. T cell mediated mucosal transformation; T.T. MacDonald, et al. Genetic events in colon carcinoma; K. Moelling, et al. Section III: Inflammatory bowel disease and malignancy. Intestinal cancer risk in patients with inflammatory bowel disease; V. Binder, et al. Incidence and significance of dysplasia in ulcerative colitis; R.H. Riddell. Endoscopic surveillance in ulcerative colitis; J. Lennard-Jones. Phenotypic and clinicopathological peculiarities of mucinous colonic carcinoma; C. Hanski, et al. Value of flow cytometry in the surveillance of patients with ulcerative colitis; R. Porschen, et al. Molecular biology of colitis-associated neoplasia; S.J. Meltzer, B.G. Greenwald. Index.
Summary
Despite recent advances, the pathogenesis and therapy of various forms of chronic inflammatory diseases of the gastrointestinal tract remains problematical. and chronic inflammatory bowel diseases, particularly ulcerative colitis, are associated with an increased incidence of carcinoma.
