Amyloid and Related Disorders - Surgical Pathology and Clinical Correlations

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits.
Amyloid and Related Disorders presents an overview of the most
recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.

List of contents

Section 1 Introduction/General :

01. Aspects of the History and Nomenclature of Amyloid and Amyloidosis - Per Westermark

02. Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis - Mario Nuvolone, Giovanni Palladini, Giampaolo Merlini

03. AA Amyloidosis- Amanda K. Ombrello, Ivona Aksentijevich

04. The Hereditary Amyloidoses- Merrill D. Benson

05. Dialysis-Associated Amyloidosis- Paweena Susantitaphong, Laura M. Dember, Bertrand L. Jaber

06. Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System- Per Westermark

07. Cerebrovascular Amyloidoses- John M. Lee, Maria M. Picken

Section 2 Non-Amyloid Protein Deposits :

08. Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Material in the Differential Diagnosis of Amyloidosis- Guillermo A. Herrera, Elba A. Turbat-Herrera





09. Light / Heavy Chain Deposition Disease as a Systemic Disorder- Guillermo A. Herrera, Elba A. Turbat-Herrera

10. Glomerulonephritis with Non-Organized Monoclonal Immunoglobulin Deposits- Pierre Ronco, Alexandre Karras, Emmanuelle Plaisier

11. Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond- Maria M. Picken

Section 3 D iagnosis :

12. Diagnosis of Amyloid Using Congo Red- Alexander J Howie

13. Diagnosis of Minimal Amyloid Deposits using the Congo Red Fluorescence Method - A Review- Reinhold P. Linke

14. Thioflavin T stain - An Easier and More Sensitive Method for Amyloid Detection- Maria M. Picken and Guillermo A. Herrera

15. Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis - Johan Bijzet, Ingrid I. van Gameren, Bouke P.C. Hazenberg

16. Generic Diagnosis of Amyloid - a Summary of Current Recommendations and the Editorial Comments on Chapters 12 - 15.- Maria M. Picken

17. Routine Use of Amyloid Typing on Formalin-fixed Paraffin Sections from 626 Patients by Immunohistochemistry- Reinhold P. Linke

18. Amyloid Typing - Experience from a Large Referral Centre - Janet A Gilbertson, Toby Hunt, Philip N. Hawkins

19. Options for Amyloid Typing in Renal Pathology - the Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations for Immunohistochemistry (Chapters 17 - 19)- Maria M. Picken

20. Amyloid Typing: Immuno-Electron Microscopy - Laura Verga, Patrizia Morbini, Giovanni Palladini, Laura Obici, Vittorio Necchi, Marco Paulli, Giampaolo Merlini

21. Classification of Amyloidosis by Mass Spectrometry Based Proteomics.- Ahmet Dogan

Section 4 A ncillary Studies of Amyloidosis :

22. Laboratory Support for Diagnosis of Amyloidosis- David L Murray, Jerry A. Katzmann,

23. Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis and Other Plasma Cell Dyscrasias- Sujata Ramamurthy, Lawreen H. Connors, Carl J. O'Hara

24. Laboratory Methods for the Diagnosis of Hereditary Amyloidoses- S. Michelle Shiller, Ahmet Dogan, Kimiyo M. Raymond, and W. Edward Highsmith, Jr.

Section 5 Organ Involvement in Amyloidoses :

25. Amyloidoses of the Kidney and Genitourinary Tract- Maria M Picken

26. Cardiac Amyloidoses- Carmela D. Tan, E. Rene Rodriguez

27. Amyloidosis of the Gastrointestinal Tract and Liver- Oscar W. Cummings, Merrill D. Benson

28. Peripheral Nerve Amyloidosis- Adam J. Loavenbruck, Janean K. Engelstad, Christopher J. Klein

Section 6 Clinical Issues and Therapy :

29. Clinical and Pathologic Issues in Patients with Amyloidosis - Practical Comments Regarding Diagnosis, Therapy and Solid Organ Transplantation- Jay Dalal, Kevin Barton, Maria M. Picken

30. Emerging Therapies for Amyloidosis- Merrill D. Benson

31. Modern Therapies in AA Amyloidosis- Amanda K. Ombrello,

32. Medicolegal Issues of Amyloidosis- Timothy Craig Allen

33. Amyloidosis from the Patient's Perspective- Muriel Finkel

Summary

Abnormal proteins are associated with a number of pathologies. This book examines recent developments in the field, including clinical presentation, etiology, pathogenesis, and differential diagnosis, as well as discussing the rationale for various therapies.

Report

From the reviews:

"This book is an outstandingly detailed review of the pathology of amyloid diseases ... . this book is a 'must read' and should be kept as a handy reference for amyloidosis centers, for pathologists and for all clinicians with an interest in amyloid diseases. The breadth of pathology is extensive, the histology presented is beyond compare and the thorough referencing is superb. The editors are to be congratulated for an outstanding resource for the pathology of amyloidosis and related disorders." (Martha Skinner, Amyloid, July, 2013)

"This comprehensive book is the first to integrate the clinical and pathological aspects of the diagnosis and treatment of amyloid and related disorders. ... It is written primarily for pathologists, but it also includes relevant information for clinical practitioners interested in the early diagnosis of amyloidoses. ... Overall this is a comprehensive, well-written, and clinically pertinent reference on amyloidosis and related disorders. ... The color images supplement well the detailed text, making it an excellent resource for pathologists as well as clinicians." (Melissa S. Jacobs, Doody's Review Service, August, 2012)

Product details

• Assisted by: Guillermo A Herrera (Editor), Ahme Dogan (Editor), Ahmet Dogan (Editor), M. D. Dogan (Editor), M.D. Dogan (Editor), Ahmet Dogan M. D. Ph. D. (Editor), Guillermo A. Herrera (Editor), M. D. Herrera (Editor), M.D. Herrera (Editor), Guillermo A. Herrera M. D. (Editor), Maria M. Picken (Editor), PhD Picken MD (Editor), Maria M. Picken MD Phd Fasn (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 18.11.2011
• EAN: 9781607613886
• ISBN: 978-1-60761-388-6
• No. of pages: 425
• Weight: 945 g
• Illustrations: 43 SW-Abb., 180 Farbabb., 31 Tabellen
• Series: Current Clinical Pathology; Current Clinical Pathology
• Subject: Natural sciences, medicine, IT, technology > Medicine