Oral Wound Healing - Cell Biology and Clinical Management - Cell Biology and Clinical Management

Informationen zum Autor Hannu Larjava, DDS, PhD, DipPerio is Professor and Chair of the Division of Periodontics at the University of British Columbia Faculty of Dentistry. Klappentext Oral Wound Healing: Cell Biology and Clinical Management brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics pertinent to the effective clinical management of oral wound healing, bringing together chapters on large dento-facial defects, dental implants, periodontal regeneration, and pulp healing.An essential synthesis of current research and clinical applications, Oral Wound Healing will be an indispensable resource for dental specialists, oral and maxillofacial surgeons as well as researchers in oral medicine and biology. Zusammenfassung * In-depth discussion of effective clinical management of oral wound healing * Detailed discussion on processes such as inflammation, reepithelialization and angiogenesis * Written by experts in the field . Inhaltsverzeichnis Contributors xiii Preface xvii 1 Oral Wound Healing: An Overview 1 Hannu Larjava Clotting and inflammation (chapters 2, 3 and 4) 1 Re-epithelialization and granulation tissue formation (chapters 5 and 6) 2 Angiogenesis (chapter 7) 3 Healing of extraction sockets (chapter 8) 4 Flap design for periodontal wound healing (chapter 9) 4 Regeneration of periodontal tissues (chapters 10 and 11) 5 Osteointegration and soft tissue healing around dental implants (chapter 12) 6 The pulp healing process (chapter 13) 7 Dermal wound healing and burn wounds (chapter 14) 7 Healing of large dentofacial defects (chapter 15) 8 References 9 2 Hemostasis, Coagulation and Complications 11 Carol Oakley and Hannu Larjava Introduction 11 Primary hemostasis 12 Secondary hemostasis and the coagulation system 13 Tertiary hemostasis 16 Tissue factor 16 Von willebrand factor 17 Other coagulation factors 17 Cell-centric model of hemostasis: from initiation to propagation 18 The procoagulant membrane 20 Membrane particles 22 Endothelium and hemostasis 22 Pro- and anticoagulant functions 22 Platelets 24 Coagulation and wound healing 26 Limitations of the waterfall cascade model and screening laboratory tests 26 Implications for laboratory tests 27 Pre-surgical evaluation to prevent bleeding problems 27 Conclusions 32 References 32 3 Inflammation and Wound Healing 39 Anna Turabelidze and Luisa Ann DiPietro Introduction 39 The innate immune response in wounds 39 Inflammatory cell infiltration into wounds 40 Inflammatory cell function in wounds 41 Cytokines and chemokines in wounds 44 Inflammation in oral mucosal wounds 47 Inflammation in fetal wounds 48 Role of inflammation in keloids 49 Inflammation and diabetic wounds 49 Conclusions 50 References 50 4 Specialized Pro-resolving Lipid Derived Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis 57 Gabrielle Fredman and Charles N. Serhan Inflammation: the cardinal signs 57 Complete resolution and tissue homeostasis is the ideal outcome of acute inflammation 58 Lipoxins, resolvins, protectins and maresins: semper ...

List of contents

Contributors xiii
 
Preface xvii
 
1 Oral Wound Healing: An Overview 1
Hannu Larjava
 
Clotting and inflammation (chapters 2, 3 and 4) 1
 
Re-epithelialization and granulation tissue formation (chapters 5 and 6) 2
 
Angiogenesis (chapter 7) 3
 
Healing of extraction sockets (chapter 8) 4
 
Flap design for periodontal wound healing (chapter 9) 4
 
Regeneration of periodontal tissues (chapters 10 and 11) 5
 
Osteointegration and soft tissue healing around dental implants (chapter 12) 6
 
The pulp healing process (chapter 13) 7
 
Dermal wound healing and burn wounds (chapter 14) 7
 
Healing of large dentofacial defects (chapter 15) 8
 
References 9
 
2 Hemostasis, Coagulation and Complications 11
Carol Oakley and Hannu Larjava
 
Introduction 11
 
Primary hemostasis 12
 
Secondary hemostasis and the coagulation system 13
 
Tertiary hemostasis 16
 
Tissue factor 16
 
Von willebrand factor 17
 
Other coagulation factors 17
 
Cell-centric model of hemostasis: from initiation to propagation 18
 
The procoagulant membrane 20
 
Membrane particles 22
 
Endothelium and hemostasis 22
 
Pro- and anticoagulant functions 22
 
Platelets 24
 
Coagulation and wound healing 26
 
Limitations of the waterfall cascade model and screening laboratory tests 26
 
Implications for laboratory tests 27
 
Pre-surgical evaluation to prevent bleeding problems 27
 
Conclusions 32
 
References 32
 
3 Inflammation and Wound Healing 39
Anna Turabelidze and Luisa Ann DiPietro
 
Introduction 39
 
The innate immune response in wounds 39
 
Inflammatory cell infiltration into wounds 40
 
Inflammatory cell function in wounds 41
 
Cytokines and chemokines in wounds 44
 
Inflammation in oral mucosal wounds 47
 
Inflammation in fetal wounds 48
 
Role of inflammation in keloids 49
 
Inflammation and diabetic wounds 49
 
Conclusions 50
 
References 50
 
4 Specialized Pro-resolving Lipid Derived Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis 57
Gabrielle Fredman and Charles N. Serhan
 
Inflammation: the cardinal signs 57
 
Complete resolution and tissue homeostasis is the ideal outcome of acute inflammation 58
 
Lipoxins, resolvins, protectins and maresins: semper vigilantes of anti-inflammation and pro-resolution 60
 
Resolution of inflammation is an actively regulated process in vivo 66
 
Resolvins and protectins are protective in experimental models of inflammatory diseases 67
 
Specialized pro-resolving lipid mediators in oral medicine: restoration of tissue homeostasis in experimental periodontitis 70
 
Resolution and wound healing 72
 
Anti-inflammation vs. Pro-resolution 72
 
Clinical implications and the development of stable analogs 74
 
Conclusions 74
 
Acknowledgments 75
 
References 75
 
5 Re-epithelialization of Wounds 81
Leeni Koivisto, Lari Häkkinen and Hannu Larjava
 
Introduction 81
 
Keratinocytes form a protective barrier between an organism and its environment 81
 
Keratinocytes are activated rapidly to restore the epithelial barrier after wounding 82
 
Many different factors contribute to re-epithelialization 84
 
Final stages of re-epithelialization 106
 
Failure to re-epithelialize: chronic wounds 107
 
Conclusions 107
 
References 108
 
6 Granulation Tissue Formation and Remod

Product details

• Authors: H Larjava, Hannu Larjava
• Assisted by: Hann Larjava (Editor), Hannu Larjava (Editor), Larjava Hannu (Editor)
• Publisher: IOWA
• Languages: English
• Product format: Hardback
• Released: 13.04.2012
• EAN: 9780813804811
• ISBN: 978-0-8138-0481-1
• No. of pages: 432
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Dentistry; Zahnmedizin, PARODONTOLOGIE, dentistry, oral biology, Periodontology, Mundheilkunde, Mundheilkunde / Biologie