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Informationen zum Autor Peter J. H. Scott is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited Linker Strategies in Solid-phase Organic Synthesis (also from Wiley) and is the series editor for the Wiley Series on Solid Phase Organic Syntheses . Brian G. Hockley is Radiopharmaceutical Quality Manager at the University of Michigan Medical School, where he works with Michael Kilbourn on radiopharmaceutical research and development. Mr. Hockley has co-authored several articles and a chapter in Linker Strategies in Solid-phase Organic Synthesis (also from Wiley). Klappentext The ultimate reference guide to the synthesis of radiopharmaceuticalsThe Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory.Volume 1 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today. It brings together in one complete, self-contained volume a collection of monographs containing a wealth of practical information from across the literature, demonstrating in meticulous detail how to prepare radiopharmaceuticals for positron emission tomography (PET) imaging, especially in tumor studies, cardiology, and neuroscience.Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals. Zusammenfassung The ultimate reference guide to the synthesis of radiopharmaceuticals The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory. Inhaltsverzeichnis Contributors ix Foreword xvii Preface xix Abbreviations xxi Part I Fluorine-18 Labeled Radiopharmaceuticals 1 1. Synthesis of [18F]-Fluorodeoxyglucose ([18F]FDG) 3 Michelle L. Richards and Peter J. H. Scott 2. Synthesis of Sodium [18F]Fluoride (Na[18F]F) 15 Brian G. Hockley and Peter J. H. Scott 3. Radiosynthesis of 3_-Deoxy-3_-[18F]Fluorothymidine ([18F]FLT) 21 Hartmuth C. Kolb, Henry C. Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh B. Gangadharmath, Vani P. Mocharla, Peter J. H. Scott, and Joseph C. Walsh 4. Synthesis of [18F]Fluoroazomycin Arabinoside ([18F]FAZA) 31 Brian G. Hockley and Peter J. H. Scott 5. Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]Fluoropropyl)-2-Nitroimidazole, [18F]FMISO) 41 Patrick J. Riss, Valentina Ferrari, Robert Bielik, Roberto Canales-Candela, Rob Smith, and Franklin I. Aigbirhio 6. Synthesis of [18F]FPPRGD2 51 Shuanglong Liu, Frederick T. Chin, Zhen Cheng, and Xiaoyuan Chen 7. Synthesis of [18F]Fluorocholine ([18F]FCH) 61 David Kryza 8. Clinical Manufacturing of [18F]-16- ¿ -Fluoroestradiol ([18F]FES) 69 Piyush Kumar and John R. Mercer 9. Synthesis of N -Succinimidyl 4-[18F]Fluorobenzoate ([18F]SFB) 81 Xia Shao 10. Synthesis of 4-(2_-Methoxyphenyl)-1-[2_-( N -2__Pyridinyl)- p -[18F]Fluorobenzamido]Ethylpiperazine [18F]MPPF 87 Marion Alvarez and Didier Le Bars 11. Synthesis of [18F]-Fallypride 95 Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio 12. Synthesis of [18F]Fluoroethyltyrosine (18F-FET) 103 Yi Zhao, Amar Alfteimi, and Maaz Zuhayra 13. Synthesis of [18F]Flumazenil ([18F]FZ) 111 Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, C...
