New Strategies in Chemical Synthesis and Catalysis

This volume represents one of the two edited by inviting a selection of young researchers participating to the European Young ChemistAward 2010. The other volume concerns the area of Nanotechnology/Material Science and is titled: Molecules at Work.This book contains the contributions of selected young chemists from the field of synthetic chemistry. The contributions are groupedunder the three following umbrella topics:Synthetic MethodsCatalysisCombinatorial and Chemical BiologyThis volume is an indispensable read for all organic and inorganic chemists, biochemists, chemists working with/on organometallics,and Ph.D. students in chemistry interested in seeing what tomorrow's chemistry will look like.

List of contents

PREFACEPART I: Synthetic MethodsELECTROSPRAY AND CRYOSPRAY MASS SPECTROMETRY: FROM SERENDIPITY TO DESIGNED SYNTHESIS OF SUPRAMOLECULAR COORDINATION AND POLYOXOMETALATE CLUSTERSIntroductionBackground to ESI-MSApplication of High-Resolution ESI-MS and CSI-MS toPolyoxometalate Cluster SystemsSpecies Identification and Probing Structural Transformations in Multi-Metallic SystemsFuture Challenges and ConclusionsEFFICIENT SYNTHESIS OF NATURAL PRODUCTS AIDED BY AUTOMATED SYNTHESIZERS AND MICROREACTORSEfficient Synthesis of Natural Products Aided by Automated SynthesizersContinuous-Flow Synthesis of Vitamin D3ConclusionsCHEMOSELECTIVE REDUCTION OF AMIDES AND IMIDESIntroductionReduction of Tertiary AmidesReduction of Secondary AmidesDehydration of Primary AmidesReduction of ImidesConclusionIONIC OZONIDES - FROM SIMPLE INORGANIC SALTS TO SUPRAMOLECULAR BUILDING BLOCKSThe Forgotten Oxygen AnionThe Synthesis of Ionic OzonidesThe Structural Variety of Ionic OzonidesMagnetic PropertiesConclusions and PerspectivesCHEMISTRY AND BIOLOGICAL PROPERTIES OF AMIDINOUREAS: STRATEGIES FOR THESYNTHESIS OF ORIGINAL BIOACTIVE HIT COMPOUNDSAmidinoureas: an IntroductionAmidinoureas in ChemistrySynthetic Strategies for the Preparation of AmidinoureasMacrocyclic AmidinoureasPerspectivesPART II: CatalysisDNA CATALYSTS FOR SYNTHETIC APPLICATIONS IN BIOMOLECULAR CHEMISTRYIntroductionIn vitro Selection of DeoxyribozymesScope of DNA-Catalyzed ReactionsSynthetic Applications of RNA-Cleaving DeoxyribozymesDNA-Catalyzed Linear Ligation of RNADNA-Catalyzed Synthesis of 2',5'-Branched Nucleic AcidsDNA-Catalyzed Synthesis of Nucleopeptide ConjugatesMechanistic Aspects of DNA CatalysisConclusions and OutlookIRON-CATALYZED CSP3 - H OXIDATION WITH H2O2: CONVERTING A RADICALREACTION INTO A SELECTIVE AND EFFICIENT SYNTHETIC TOOLIntroduction and ScopeEnvironmentally Benign C - H OxidationInspiration from NatureMechanistic ConsiderationsBioinspired C - H Oxidation CatalystsPerspectivesHYDROGEN BONDS AS AN ALTERNATIVE ACTIVATIONIntroductionThiourea CatalystsConclusionsELECTROSYNTHESIZED STRUCTURED CATALYSTS FOR H2 PRODUCTIONIntroductionPreparation of Structured CatalystsElectrosynthesisElectrosynthesis of Hydrotalcite-Type CompoundsSummary and OutlookMICROKINETIC ANALYSIS OF COMPLEX CHEMICAL PROCESSES AT SURFACESIntroductionTime and Length Scales in Heterogeneous CatalysisHierarchical Multiscale Approach for Microkinetic Model DevelopmentShow Case: Microkinetic Analysis of CH4 Partial Oxidation on RhConclusionsSYNTHETIC POTENTIAL BEHIND GOLD-CATALYZED REDOX PROCESSESIntroductionGold-Catalyzed Reactions Involving Oxygen FunctionalitiesGold-Catalyzed Reactions Involving Nitrogen FunctionalitiesGold-Catalyzed Reactions Involving C - C Bond FormationGold-Catalyzed Reactions Involving Alkene DifunctionalizationGold-Catalyzed Reactions Involving Halogen FunctionalitiesSummary and OutlookTRANSITION-METAL COMPLEXES IN SUPPORTED LIQUID PHASE AND SUPERCRITICAL FLUIDS - A BENEFICIAL COMBINATION FOR SELECTIVECONTINUOUS-FLOW CATALYSIS WITH INTEGRATED PRODUCT SEPARATIONStrategies for Catalyst Immobilization Using Permanent Separation BarriersSupported Liquid-Phase Catalysts Based on Organic Solvents (SLP)Supported Aqueous-Phase Catalysts (SAP)Supported Ionic Liquid-Phase Catalysts (SILP)Supported Liquid-Phase Catalysts and Supercritical FluidsConclusionPART III: Combinatorial and Chemical BiologyINHIBITING PATHOGENIC PROTEIN AGGREGATION: COMBINATORIAL CHEMISTRY IN COMBATING ALPHA-1 ANTITRYPSIN DEFICIENCYIntroductiona1-Antitrypsin DeficiencyTargeting the s4A Site with the Peptide Annealing MethodExpanding the Molecular DiversityCharacterization of the Combinatorially Selected PeptideConclusion and OutlookSYNTHESIS AND APPLICATION OF MACROCYCLES USING DYNAMIC COMBINATORIAL CHEMISTRYSupramolecular ChemistryDynamic Combinatorial ChemistryIon Transport across Membranes Mediated by a Dynamic Combinatorial LibraryTOWARD TOMORROW'S DRUGS: THE SYNTHESIS OF COMPOUND LIBRARIES BY SOLID-PHASE CHEMISTRYIntroductionSolid-Phase Synthesis of Selected Privileged StructuresConclusions and Outlook

About the author

Bruno Pignataro, born in Bologna in 1972, is Professor of Physical Chemistry at the University of Palermo. He received his degree in chemistry in 1995 from the University of Catania and his PhD in materials science five years later. He has helped establish a wide network of international collaborations and organized more than 10 meetings at national and international level, including coordinating the Young Chemists Group of the Italian Chemical Society and chairing the 1st and the 2nd European Young Chemist Award. He is a referee for several leading chemistry and materials journals, has more than 50 scientific publications and about 80 conference communications to his name, along with several invited lectures.§Professor Pignataros research interests focus on the related fields of the physical chemistry of molecular surfaces and soft nanotechnologies. He is in the Editorial Board of Chemistry Central Journal, is editing by La Chimica e l'Industria a new heading on Critical Reviews and also acted as the editor of the recently published book, 'Tommorow's Chemistry Today: Concepts in Nanoscience, Organic Materials and Environmental Chemistry', which provides an overview of rising young scientists in the fields of organic materials, nanotechnology and environmental chemistry.

Summary

This volume represents one of the two edited by inviting a selection of young researchers participating to the European Young Chemist
Award 2010. The other volume concerns the area of Nanotechnology/Material Science and is titled: Molecules at Work.
This book contains the contributions of selected young chemists from the field of synthetic chemistry. The contributions are grouped
under the three following umbrella topics:

Synthetic Methods
Catalysis
Combinatorial and Chemical Biology

This volume is an indispensable read for all organic and inorganic chemists, biochemists, chemists working with/on organometallics,
and Ph.D. students in chemistry interested in seeing what tomorrow's chemistry will look like.

Product details

• Authors: Bruno Pignataro
• Assisted by: Brun Pignataro (Editor), Bruno Pignataro (Editor)
• Publisher: Wiley-VCH
• Languages: English
• Product format: Hardback
• Released: 01.04.2012
• EAN: 9783527330904
• ISBN: 978-3-527-33090-4
• No. of pages: 384
• Dimensions: 173 mm x 245 mm x 23 mm
• Weight: 896 g
• Illustrations: 102 SW-Abb., 30 Farbabb., 25 Tabellen
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Chemie, Anorganische Chemie, Organische Chemie, ORGANIC CHEMISTRY, Katalyse, CHEMISCHE SYNTHESE, chemistry, Catalysis, Inorganic Chemistry, Biochemie u. Chemische Biologie, Biochemistry (Chemical Biology)