Medical Biochemistry at a Glance

Informationen zum Autor J. G. Salway is the author of Medical Biochemistry at a Glance, 3rd Edition, published by Wiley. Klappentext Offering a concise, illustrated summary of biochemistry and its relevance to clinical medicine, Medical Biochemistry at a Glance is intended for students of medicine and the biomedical sciences such as nutrition, biochemistry, sports science, medical laboratory sciences, physiotherapy, pharmacy, physiology, pharmacology, genetics and veterinary science. It also provides a succinct review and reference for medical practitioners and biomedical scientists who need to quickly refresh their knowledge of medical biochemistry.The book is designed as a revision guide for students preparing for examinations and contains topics that have been identified as 'high-yield' facts for the United States Medical Licensing Examination (USMLE), Step 1.This third edition:* Has been thoroughly revised and updated and is now in full colour throughout* Is written by the author of the hugely successful Metabolism at a Glance (ISBN 9781405107167)* Features updated and improved clinical correlates* Expands its coverage with a new section on Molecular Biology* Includes a brand new companion website of self-assessment questions and answers at www.ataglanceseries.com/medicalbiochemistry Zusammenfassung Medical Biochemistry at a Glance is a concise, illustrated summary of biochemistry and its relevance to clinical medicine. It is intended for students of medicine and the biomedical sciences such as nutrition, biochemistry, sports science, medical laboratory sciences, physiotherapy, pharmacy, physiology, pharmacology and veterinary science. Inhaltsverzeichnis Preface to the third edition 7 Acknowledgements to the third edition 7 Figure key 8 SI/mass unit conversions 9 Part 1 Acids, bases and pH 1 Acids, bases and hydrogen ions (protons) 10 2 Understanding pH 12 3 Production and removal of protons into and from the blood 14 4 Metabolic alkalosis and metabolic acidosis 16 5 Respiratory alkalosis and respiratory acidosis 18 Part 2 Structure of amino acids and proteins 6 Amino acids and the primary structure of proteins 20 7 Secondary structure of proteins 22 8 Tertiary and quaternary structure and collagen 24 Part 3 Formation of ATP: oxidation and reduction reactions 9 Oxidation/reduction reactions, coenzymes and prosthetic groups 26 10 Anaerobic production of ATP by substrate-level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction 28 11 Aerobic production of ATP 30 12 Biosynthesis of ATP by oxidative phosphorylation I 32 13 Biosynthesis of ATP by oxidative phosphorylation II 34 14 What happens when protons or electrons leak from the respiratory chain? 36 15 Free radicals, reactive oxygen species and oxidative damage 38 16 Aerobic oxidation of glucose to provide energy as ATP 40 17 Anaerobic oxidation of glucose by glycolysis to form ATP and lactate 42 18 Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG) and the Bohr effect 44 Part 4 Carbohydrates 19 Carbohydrates 46 20 Absorption of carbohydrates and metabolism of galactose 48 21 Fate of glucose in liver: glycogenesis and lipogenesis 50 22 Fructose metabolism 52 23 Glucose homeostasis 54 24 Glucose-stimulated secretion of insulin from ß-cells 56 25 Regulation of glycogen metabolism 58 26 Glycogen breakdown (glycogenolysis) and glycogen storage diseases 60 27 Insulin signal transduction and diabetes mellitus 62 28 Diabetes mellitus 64 29 Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis 66 Part 5 Enzymes and regulation of pathways 30 Enzymes: nomenclature, kinetics and i...

List of contents

Preface to the third edition 7
 
Acknowledgements to the third edition 7
 
Figure key 8
 
SI/mass unit conversions 9
 
Part 1 Acids, bases and pH
 
1 Acids, bases and hydrogen ions (protons) 10
 
2 Understanding pH 12
 
3 Production and removal of protons into and from the blood 14
 
4 Metabolic alkalosis and metabolic acidosis 16
 
5 Respiratory alkalosis and respiratory acidosis 18
 
Part 2 Structure of amino acids and proteins
 
6 Amino acids and the primary structure of proteins 20
 
7 Secondary structure of proteins 22
 
8 Tertiary and quaternary structure and collagen 24
 
Part 3 Formation of ATP: oxidation and reduction reactions
 
9 Oxidation/reduction reactions, coenzymes and prosthetic groups 26
 
10 Anaerobic production of ATP by substrate-level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction 28
 
11 Aerobic production of ATP 30
 
12 Biosynthesis of ATP by oxidative phosphorylation I 32
 
13 Biosynthesis of ATP by oxidative phosphorylation II 34
 
14 What happens when protons or electrons leak from the respiratory chain? 36
 
15 Free radicals, reactive oxygen species and oxidative damage 38
 
16 Aerobic oxidation of glucose to provide energy as ATP 40
 
17 Anaerobic oxidation of glucose by glycolysis to form ATP and lactate 42
 
18 Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG) and the Bohr effect 44
 
Part 4 Carbohydrates
 
19 Carbohydrates 46
 
20 Absorption of carbohydrates and metabolism of galactose 48
 
21 Fate of glucose in liver: glycogenesis and lipogenesis 50
 
22 Fructose metabolism 52
 
23 Glucose homeostasis 54
 
24 Glucose-stimulated secretion of insulin from ²-cells 56
 
25 Regulation of glycogen metabolism 58
 
26 Glycogen breakdown (glycogenolysis) and glycogen storage diseases 60
 
27 Insulin signal transduction and diabetes mellitus 62
 
28 Diabetes mellitus 64
 
29 Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis 66
 
Part 5 Enzymes and regulation of pathways
 
30 Enzymes: nomenclature, kinetics and inhibitors 68
 
31 Regulation of enzyme activity 70
 
32 Regulation of glycolysis and Krebs cycle 72
 
33 Oxidation of fatty acids to produce ATP in muscle and ketone bodies in liver 74
 
34 Regulation of lipolysis, ²-oxidation, ketogenesis and gluconeogenesis 76
 
Part 6 Lipids and lipid metabolism
 
35 Structure of lipids 78
 
36 Phospholipids I: phospholipids and sphingolipids 80
 
37 Phospholipids II: micelles, liposomes, lipoproteins and membranes 82
 
38 Metabolism of carbohydrate to cholesterol 84
 
39 VLDL and LDL metabolism I: "forward" cholesterol transport 86
 
40 VLDL and LDL metabolism II: endogenous triacylglycerol transport 88
 
41 HDL metabolism: "reverse" cholesterol transport 90
 
42 Absorption and disposal of dietary triacylglycerols and cholesterol by chylomicrons 92
 
43 Steroid hormones: aldosterone, cortisol, androgens and oestrogens 94
 
Part 7 Metabolism of amino acids and porphyrins
 
44 Urea cycle and overview of amino acid catabolism 96
 
45 Non-essential and essential amino acids 98
 
46 Amino acid metabolism: to energy as ATP; to glucose and ketone bodies 100
 
47 Amino acid disorders: maple syrup urine disease, homocystinuria, cystinuria, alkaptonuria and albinism 102
 
48 Phenylalanine and tyrosine metabolism in health and disease 104
 
49 Products of tryptophan and

Report

I have taught biochemistry to medical students and to undergraduates and graduate students, at both Temple University School of Medicine and at Case Western Reserve University, since 1968, so that I have had a great deal of experience in the field and have a feel for what works well for medical students.
Medical Biochemistry at a Glance would be an excellent book for USMLE Step 1. In my experience, medical students (and pre-medical students) would greatly benefit from reading it in preparation for the exam.
This compares very well with Lippincott's Biochemistry - this has the right price and approach to compete with Lippincott for a less expensive and more accessible alternative to the larger text books that are out there.
I like the way it combines the metabolic pathways and principles in such a creative fashion, and the metabolism sections are among the best I have read and the easiest to understand. Metabolism is a very complicated subject and, in my experience, most teachers of the subject would really benefit from your text. (Richard W. Hanson, Case Western Reserve University School of Medicine)

Product details

• Authors: J G Salway, J. G. Salway, Salway J. G.
• Publisher: Blackwell Scientific Publishers Ltd
• Languages: English
• Product format: Paperback / Softback
• Released: 20.01.2012
• EAN: 9780470654514
• ISBN: 978-0-470-65451-4
• Dimensions: 223 mm x 278 mm x 12 mm
• Series: At a Glance; At a Glance
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; Medizin, Medical Science, Basic Medical Sciences, Medizinische Grundlagenfächer