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Barrett's Esophagus gives an extensive overview written by the world's leading experts covering the epidemiology, gastroenterology and surgery, as well as the molecular basis of:
- the precursor lesions leading to the development of Barrett's epithelium;
- the unique characteristics of Barrett's esophagus;
- the consequences of malignant degeneration, i.e. adenocarcinoma.
All aspects in terms of diagnosis, secondary prevention, multimodality, medical and surgical treatment are elucidated.
List of contents
Norman Barrett and the esophagus.- Section 1: Normal Anatomy and Physiology of the Esophagus.- 1.1 Anatomy and embryology of the esophagus.- 1.2 Cell biology of the esophageal epithelium.- 1.3 Normal physiology of the esophagus.- 1.4 Pathophysiology of gastro-esophageal reflux disease.- Section 2: Gastro-Esophageal Reflux Disease.- 2.1 The natural history of gastro-esophageal reflux disease.- 2.2 Helicobacter pylori and reflux disease.- 2.3 Acid and bile in the esophagus.- 2.4 Endoscopie classification of gastro-esophageal reflux disease.- 2.5 Optimal surgical therapy for anti reflux disease.- 2.6 Surgical treatment of duodeno-gastro esophageal reflux.- Section 3: Barrett's Esophagus - Diagnosis.- 3.1 Histopathology of Barrett's esophagus.- 3.2 The metaplasia-dysplasia-carcinoma sequence of Barrett's esophagus.- 3.3 Genetic alterations.- 3.4 Endoscopic surveillance.- 3.5 Short segment Barrett's esophagus and intestinal metaplasia at the gastro-esophageal junction.- Section 4: Barrett's Esophagus - Treatment.- 4.1 Prevention of cancer by control of reflux.- 4.2 Prevention of cancer in Barrett's by ablation.- 4.3 The role of ablation in the management of high-grade dysplasia.- 4.4 Surgical treatment of high-grade dysplasia and superficial carcinoma.- Section 5: Adenocarcinoma in Barrett's.- 5.1 Epidemiology of Barrett's esophagus and adenocarcinoma.- 5.2 Adenocarcinoma in Barrett's esophagus: signs, symptoms and endoscopic appearance.- 5.3 Adenocarcinoma in Barrett's esophagus: classification and staging.- 5.4 Diagnosis and implications of bone marrow micrometastases.- Section 6: Treatment of Adenocarcinoma.- 6.1 Indications and outcome of esophageal resection.- 6.2 Transhiatal esophagectomy.- 6.3 Resection of esophageal carcinoma: the role of lymfnode dissection.- 6.4 Videoendoscopic esophagectomy for cancer.- 6.5 Management of postoperative complications.- 6.6 Multimodality in the management of adenocarcinoma of the esophagus.- 6.7 Endoscopie management of dysphagia from esophageal cancer.- Section 7: Quality of Life.- 7.1 Function and quality of life after esophageal resection.
Summary
Barrett's Esophagus gives an extensive overview written by the world's leading experts covering the epidemiology, gastroenterology and surgery, as well as the molecular basis of:
- the precursor lesions leading to the development of Barrett's epithelium;
- the unique characteristics of Barrett's esophagus;
- the consequences of malignant degeneration, i.e. adenocarcinoma.
All aspects in terms of diagnosis, secondary prevention, multimodality, medical and surgical treatment are elucidated.
