Cardiac Ischemia: From Injury to Protection - From Injury to Protection

Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.

List of contents

1 Myocardial Hypoxia and Ischemia.- 2 Irreversible Myocardial Ischemic Injury.- 3 Reperfusion-Induced Injury.- 4 Myocardial Vasculature during Ischemia and Reperfusion.- 5 Cardiac Protection.- 6 Developmental Aspects of Cardiac Ischemia and Protection.- References.

Product details

• Authors: Frantisek Kolár, Bohuslav Ost'ádal
• Assisted by: Kolár (Editor), Kolár (Editor), Frantisek Kolár (Editor), Bohusla Ost'ádal (Editor), Bohuslav Ost'ádal (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 20.10.2010
• EAN: 9781441951052
• ISBN: 978-1-4419-5105-2
• No. of pages: 173
• Dimensions: 155 mm x 10 mm x 235 mm
• Weight: 301 g
• Illustrations: XVI, 173 p.
• Series: Basic Science for the Cardiologist; Basic Science for the Cardiologist
• Subject: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine