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This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis.
Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field.
All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.
A must for all chemists and biotechnologists.
List of contents
VOLUME 1
PART I PRINCIPLES OF ENZYME CATALYSIS
Introduction - Principles and Historical Landmarks of Enzyme Catalysis in Organic Synthesis
Concepts in Biocatalysis
Discovery of Enzymes
Rational Design of Enzymes
Directed Evolution of Enzymes
Production and Isolation of Enzymes
Reaction and Process Engineering
PART II HYDROLYSIS AND FORMATION OF C-O BONDS
Hydrolysis and Formation of Carboxylic Acid Esters
Hydrolysis and Formation of Epoxides
Hydrolysis and Formation of Glycosidic Bonds
Addition of Water to C¼C Bonds and its Elimination
Industrial Application and Processes Forming C-O Bonds
VOLUME 2
PART III HYDROLYSIS AND FORMATION OF C-N BONDS
Hydrolysis of Nitriles to Amides
Hydrolysis of Nitriles to Carboxylic Acids
Hydrolysis of Amides
Hydrolysis and Formation of Hydantoins
Hydrolysis and Synthesis of Peptides
C-N Lyases Catalyzing Addition of Ammonia, Amines, and Amides to C¼C and C¼O Bonds
Application of Transaminases
Industrial Applications and Processes Using Enzymes Acting on C-N Bonds
PART IV FORMATION AND CLEAVAGE OF C-C BONDS
Aldol Reactions
Acyloin and Benzoin Condensations
Cleavage and Formation of Cyanohydrins
Industrial Application and Processes Using Carbon-Carbon Lyases
PART V HYDROLYSIS AND FORMATION OF P-O BONDS
Hydrolysis and formation of P-O Bonds
PART VI REDUCTIONS
Reduction of Ketones and Aldehydes to Alcohols
Reduction of C¼C Double Bonds
Reductive Amination of Keto Acids
Industrial Application of Oxidoreductase catalyzed Reduction of Ketones and Aldehydes
VOLUME 3
PART VII OXIDATIONS
Oxyfunctionalization of C-H Bonds
Oxyfunctionalization of C-C Multiple Bonds
Oxidation of Alcohols, Aldehydes, and Acids
Baeyer-Villiger Oxidations
Aromatic Oxidations
Oxidation of C-N Bonds
Oxidation at Sulfur and Oxidation of Amino Groups
Halogenation
Industrial Application and Processes Using Biocatalysts for Oxidation Reactions
PART VIII ISOMERIZATIONS
Isomerizations
Industrial Application and Processes Using Isomerases
PART IX EXTENDED APPLICATIONS OF ENZYME CATALYSIS
Enzymatic Catalytic Promiscuity and the Design of New Enzyme Catalyzed Reactions
Catalytic Antibodies
Chemoenzymatic Dynamic Kinetic Resolution and Related Dynamic Asymmetric Transformations
Biocatalysis in Material Science
Industrial Applications of Enzymes in Emerging Areas
PART X TABULAR SURVEY OF AVAILABLE ENZYMES
Tabular Survey of Available Enzymes
About the author
Harald Gröger is currently working at the Degussa AG. His research is focussed on enzymatic reactions and biocatalysis.
Summary
This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis.
Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field.
All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.
A must for all chemists and biotechnologists.
Report
"The editors are to be congratulated on the high standard of presentation in the 45 chapters - the whole work is a masterpiece! Almost 2000 pages of very enjoyable reading. I hope that the editors are already planning a 4 th edition in the next 10 years." ( Organic Process Research & Development Journal , 1 April 2013)
