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Klappentext The largest collection of articles on the three major gene families, this work ranges from enzymology to molecular biology to physiological implications. The three gene families are related in that the enzymes catalyse the NAD(P) dependent oxidation or reduction of carbonyl containing substrates. The substrates are important in diverse areas such as alcoholism, diabetes and cancer related problems as well as simple detoxification. The scope of the chapters, contributed by leading international scientists, is wide and covers gene regulation to enzyme mechanisms and protein structure. This is the only publication dealing in such depth with just three gene families. An important reference for researchers in toxicology and molecular biology. Inhaltsverzeichnis ALDEHYDE DEHYDROGENASE. 1. Order and disorder in mitochondrial aldehyde dehydrogenase (T. Hurley, S. Parmley, H. Breen). 2. Chemical mechanisms and substrate binding sites of NADP-dependent aldehyde dehydrogenase from streptococcus mutans (S. Marchal, D. Cobessi, S. Rahuel-Clermont, F. Tete-Favier, A. Aubry, G. Branlant). 3. Differences in nucleotide specificity and catalytic mechanism between vibrio harveyi aldehyde dehydrogenase and other members of the aldehyde dehydrogenase superfamily (Lei Zhang, B. Ahvazi, R. Szittner, A. Vrielink, E. Meighen). 4. Beyond the catalytic core of ALDH: A web of important residues begins to emerge (J. Hempel, R. Lindahl, J. Perozich, Bi-Cheng Wang, I. Kuo, H. Nicholas). 5. Subunit communication in tetrameric class 2 human liver aldehyde dehydrogenase as the basis for half-of-the-site reactivity and the dominance of the oriental subunit in a heterotetramers (H. Weiner, Baoxian Wei, Jianzhong Zhou). 6. Interaction of sheep liver cytosolic aldehyde dehydrongenase with quercetin, resveratrol and diethylstilbestrol (T. M. Kitson, K.E. Kitson, S.A. Moore). 7. Complexes of NADH with betaine aldehyde dehydrogenase from leaves of the plant Amaranthus Hypochondriacus (R. A. Munoz, C. Mujica-Jimenez). 8. Overview - In Vitro inhibition of aldehyde dehydrogenase by disulfiram and metabolites (J. J. Lipsky, M. L. Shen, S. Naylor). 9. In Vivo inhibition of aldehyde dehydrogenase by disulfiram (J. J. Lipsky, M. L. Shen, S. Naylor). 10. Catalysis of dehydrogenation of 4-trans-(N,N-dimethylamino)cinnamaldehyde by aldehyde dehydrogenase (R. Pietruszko, T. Lehmann, M. Dryjanski, D. P. Abriola, W. Ambroziak). 11. Coenzyme specificity in aldehyde dehydrogenase (J. Perozich, I. Kuo, R. Lindahl, J. Hempel). 12. Interaction of human aldehyde dehydrogenase with aromatic substrates and ligands (A. Allali-Hassani, H. Weiner). 13. Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues (N. E. Sladek, G.K. Rekha, M. J. C. Lee, H. T. Nagasawa). 14. Role of the C-terminal tail on the quaternary structure of aldehyde dehydrogenase (J. Rodriguez-Zavala, H. Weiner). 15. Purification and characterization of grass carp mitochondrial aldehyde dehydrogenase (Wing-Ping Fong, Ka-Fai Choy). 16. Making an oriental equivalent of the yeast cystosolic aldehyde dehydrogenase as well as making one with positive cooperativity in coenzyme binding by mutations of glutamate 492 and arginine 480 (Baoxian Wei, H. Weiner). 17. Corneal and stomach expression of aldehyde dehydrogenases: From fish to mammals (A. Pappa, N.A. Sophos, V. Vasiliou). 18. Betaine aldehyde dehydrogenase from rate liver mitochondrial matrix (R. Pietruszko, Ming-Kai Chern). 19. Molecular dynamics simulation of class 3 aldehyde dehydrogenase (T. Wymore, H.B. Nicholas, J. Hempel). 20. Inhibition of mouse aldehyde dehydrogenase 2 activity by the oriental variant of the human aldehyde dehydrogenase 2 gene (Jingjua-Jeng, D. Goldman, T. T.-Y. Wang, H. Weiner, B. J. Song). 21. The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumor ...
